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Calcium release-activated calcium channel protein 1

Activates NFATC2/NFAT1 and NFATC3/NFAT4-mediated transcriptional responses. … Pore-forming subunit of two major inward rectifying Ca(2+) channels at the plasma membrane: Ca(2+) release-activated Ca(2+) (CRAC) channels and arachidonate-regulated Ca(2+)-selective (ARC) channels (Probable

Mitogen-activated protein kinase kinase kinase 5

Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases … These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1)

Calcium-activated potassium channel subunit beta-2

Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. … Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex.

Calcium-activated potassium channel subunit beta-4

Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. … Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics.

Mitogen-activated protein kinase kinase kinase 19

Mitogen-activated protein kinase kinase kinase 10

Activates the JUN N-terminal pathway

Mitogen-activated protein kinase kinase kinase 12

Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1 (PubMed:28111074). … May be an activator of the JNK/SAPK pathway

Mitogen-activated protein kinase kinase kinase 4

Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6

Sodium/potassium-transporting ATPase subunit alpha-1

Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity … This process maintains essential Na(+) and K(+) gradients for membrane potential and cellular function.

ATP synthase subunit c, sodium ion specific

F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane sodium channel, linked together by a central stalk and a peripheral … F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient.