Sodium/potassium-transporting ATPase subunit alpha-1

BE0000732ProteinHumansATP1A1

Catalytic subunit of the Na(+)/K(+)-ATPase pump that hydrolyzes ATP to exchange ions across the plasma membrane, exporting 3 Na(+) and importing 2 K(+) per cycle against electrochemical gradients (PubMed:29499166, PubMed:30388404, PubMed:35803952). It is acted on by 34 drugs in DrugBank.

Gene name
ATP1A1
UniProtKB entry
P05023Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,023 residues · 112,895 Da
Also known as
7.2.2.13 · Na(+)/K(+) ATPase alpha-1 subunit · Sodium pump subunit alpha-1

Resolves to

Protein
UniProtP05023UniProt nameAT1A1_HUMAN
Gene
HGNCHGNC:799NCBI Gene476GenBank219942GeneCardsATP1A1
Pharmacology
KEGGhsa:476
Structure
PDB7E1ZPDB7E20PDB7E21
Drugs

What you can answer from here — as of September 07, 2019

34DrugsApproved to experimental, with action, bond type and pharmacological action
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19GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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140+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sodium/potassium-transporting ATPase subunit alpha-1, how selective are they, and which programs against it are still in active trials?

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