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Displaying results 161 - 170 of 134146 in total
  1. Pathway

    Iminoglycinuria

    smpdb.ca/view/SMP0000193
    Disease

    This disorder is characterized by a large accumulation of glycine, proline, and hydroxyproline in the urine. Symptoms of the disorder include urolithiasis and mental retardation. … SLC36A2 codes for a proton-coupled amino acid transporter which facilitates the reuptake of glycine, proline, and hydroxyproline.

    Drugs: Cysteine · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Chloride channel protein ClC-Ka
  2. Pathway

    Glucose Transporter Defect (SGLT2)

    smpdb.ca/view/SMP0000245
    Disease

    This defect causes massive accumulation of glucose in the urine, and symptoms include glucosuria. … reabsorptive mechanism for D-glucose in the kidney is known to involve a lower affinity, high capacity Na()/glucose cotransporter, which is located in the early proximal convoluted tubule segment S1 and

    Drugs: Cysteine · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Chloride channel protein ClC-Ka
  3. Pathway

    Blue Diaper Syndrome

    smpdb.ca/view/SMP0000583
    Disease

    Treatment can include a calcium restricted diet in order to prevent hypercalcemia, and a tryptophan restricted diet to prevent all systems. … Other symptoms can include bacterial infections, damage to various parts of the eye, hypercalcemia, and impaired kidney function due to this.

    Drugs: Cysteine · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Chloride channel protein ClC-Ka
  4. Pathway

    Lysinuric Protein Intolerance (LPI)

    smpdb.ca/view/SMP0000585
    Disease

    Symptoms of the disorder include failure to thrive after weaning, nausea and vomiting following a meal containing large amounts of protein, as well as osteoporosis, and lung and kidney problems. … It is estimated that the LPI affects 1 in 60,000 individuals in certain populations such as in Finland and Japan, and less frequently outside these populations.

    Drugs: Cysteine · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Chloride channel protein ClC-Ka
  5. Pathway

    Triamterene Action Pathway (New)

    smpdb.ca/view/SMP0126281
    Drug action

    Triamterene maintains or increases sodium excretion, thereby increasing the excretion of water, and reducing the excess loss of potassium, hydrogen, and chloride ions by inhibiting the distal tubular exchange … sodium uptake and potassium secretion.

    Drugs: Triamterene · Potassium cation · Urea
    Enzymes: Chloride channel protein ClC-Ka
  6. Pathway

    Misoprostol Action Pathway

    smpdb.ca/view/SMP0124718
    Drug action

    Misoprostol may also promote ulcer healing by increasing mucus and bicarbonate secretion and thickening the mucosal bilayer so the mucosa can generate new cells. … With reduced protein kinase A activation, this decreases the activity of the proton pump, fewer H+ ions are pumped into the lumen, reducing the acidity and thus allowing stomach ulcers to heal and reducing

    Drugs: ATP · Misoprostol · Potassium cation · Magnesium cation · Zinc · Cyclic adenosine monophosphate +1 more
    Enzymes: Chloride anion exchanger
  7. Pathway

    Latanoprost Action Pathway

    smpdb.ca/view/SMP0175204
    Drug action

    Latanoprost may also promote ulcer healing by increasing mucus and bicarbonate secretion and thickening the mucosal bilayer so the mucosa can generate new cells. … With reduced protein kinase A activation, this decreases the activity of the proton pump, fewer H+ ions are pumped into the lumen, reducing the acidity and thus allowing stomach ulcers to heal and reducing

    Drugs: ATP · Latanoprost · Potassium cation · Magnesium cation · Zinc · Cyclic adenosine monophosphate +1 more
    Enzymes: Chloride anion exchanger
  8. Pathway

    Dinoprost tromethamine Action Pathway

    smpdb.ca/view/SMP0175205
    Drug action

    Dinoprost tromethamine may also promote ulcer healing by increasing mucus and bicarbonate secretion and thickening the mucosal bilayer so the mucosa can generate new cells. … With reduced protein kinase A activation, this decreases the activity of the proton pump, fewer H+ ions are pumped into the lumen, reducing the acidity and thus allowing stomach ulcers to heal and reducing

    Drugs: ATP · Dinoprost tromethamine · Potassium cation · Magnesium cation · Zinc · Cyclic adenosine monophosphate +1 more
    Enzymes: Chloride anion exchanger
  9. Pathway

    Tafluprost Action Pathway

    smpdb.ca/view/SMP0175201
    Drug action

    Tafluprost may also promote ulcer healing by increasing mucus and bicarbonate secretion and thickening the mucosal bilayer so the mucosa can generate new cells. … With reduced protein kinase A activation, this decreases the activity of the proton pump, fewer H+ ions are pumped into the lumen, reducing the acidity and thus allowing stomach ulcers to heal and reducing

    Drugs: ATP · Potassium cation · Magnesium cation · Zinc · Cyclic adenosine monophosphate · Pyrophosphoric acid +1 more
    Enzymes: Chloride anion exchanger
  10. Pathway

    Travoprost Action Pathway

    smpdb.ca/view/SMP0175203
    Drug action

    Travoprost may also promote ulcer healing by increasing mucus and bicarbonate secretion and thickening the mucosal bilayer so the mucosa can generate new cells. … With reduced protein kinase A activation, this decreases the activity of the proton pump, fewer H+ ions are pumped into the lumen, reducing the acidity and thus allowing stomach ulcers to heal and reducing

    Drugs: ATP · Travoprost · Potassium cation · Magnesium cation · Zinc · Cyclic adenosine monophosphate +1 more
    Enzymes: Chloride anion exchanger