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Cimetidine H2 Anti-Histamine Action Pathway
smpdb.ca/view/SMP0123152Drug actionCimetidine is an H2 receptor antagonist drug that is mainly used to treat peptic ulcers and heartburns. … It works by acting as a competitive inhibitor and blocks the action of histamine on Histamine H2 receptors.
Drugs: ATP · Cimetidine · Potassium cation · Magnesium cation · Zinc · Cyclic adenosine monophosphatePhysostigmine Action Pathway (new)
smpdb.ca/view/SMP0126616Drug actionPhysostigmine acts on the acetylcholinesterase enzyme and inhibits it so it cannot break down acetylcholine. … By doing so it keeps acetylcholine available within the synaptic cleft continuing to act on nicotinic and muscarinic receptors.
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit beta-1Tacrine Action Pathway (new)
smpdb.ca/view/SMP0126621Drug actionIts mechanism of action is not fully known but is thought that the drug reversibly binds and inhibits cholinesterase and acetylcholinesterase. … Stopping the breakdown of acetylcholine leads to cholinergic receptors being further stimulated and accumulating in the synaptic cleft.
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit beta-1Edrophonium Action Pathway (new)
smpdb.ca/view/SMP0126690Drug actionThis increases cholinergic transmission and stimulates nicotinic acetylcholine receptors and initiates muscle contraction. … Some symptoms of an overdose may include nausea, vomiting, diarrhea, sweating, bradycardia, and increased secretions in the bronchioles and saliva.
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit alpha-1FDistigmine Action Pathway
smpdb.ca/view/SMP0126700Drug actionThis is an experimental drug that acts by inhibiting cholinesterase and also binds directly to nicotinic and muscarinic receptors in order to stimulate detrusor muscles in those who suffer from detrusor … Distigmine is a cholinesterase inhibitor, a parasympathomimetic agent used in the treatment of neurogenic bladder dysfunction and or myasthenia gravis.
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit alpha-1FCarbaryl Action Pathway
smpdb.ca/view/SMP0126728Drug actionIt acts on insects and due to its relative dosage compared to a human, the lice having their acetylcholinesterase inhibited leading to muscle spasm and eventually death. … Carbaryl is an insecticide in addition to a cholinesterase inhibitor it is used as a treatment to remove head lice.
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit alpha-1FProcyclidine M1 Antispasmodic Action Pathway
smpdb.ca/view/SMP0126398Drug actionA muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorders and in parkinsonism. … It is thought that Procyclidine acts by blocking central cholinergic receptors, and thus balancing cholinergic and dopaminergic activity in the basal ganglia.
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit beta-1Donepezil Action Pathway
smpdb.ca/view/SMP0126613Drug actionDonepezil is an acetylcholinesterase inhibitor also known as Adlarity, Aricept and Namzaric, that is used in the treatment of Alzheimer's Disease and dementia. … Donepezil goes through first-pass metabolism by CYP3A4 and CYP2D6 into metabolites which can be further broken down by dealkylation, hydroxylation, oxidation, hydrolysis and glucuronidation.
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit beta-1Galantamine Action Pathway (new, revision)
smpdb.ca/view/SMP0126671Drug actionThe drug is metabolized by enzymes CYP2D6 and CYP3A4 into metabolites. … These symptoms of cognitive loss are due to acetylcholine deficiency, galantamine inhibiting acetylcholinesterase and cholinesterase, which increases extracellular levels of acetylcholine.
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit beta-1Minaprine Acetylcholinesterase Antidepressant Action Pathway
smpdb.ca/view/SMP0126689Drug actionFirstly, this drug binds as an antagonist to the serotonin type 2 receptors (C, B, and C). Secondly, it can also antagonize the dopamine D1 and D2 type receptors. … The first one is found in cells located in the periphery and breakdown serotonin, norepinephrine, epinephrine, dopamine, and tyramine.
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit beta-1