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Displaying results 161 - 167 of 167 in total
  1. Target

    ADP/ATP translocase 2

    go.drugbank.com/bio_entities/BE0000709
    TargetHumans

    production and cause mitochondrial thermogenesis (By similarity). … ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity).

    Synonyms: ANT 2
  2. Target

    ADP/ATP translocase 1

    go.drugbank.com/bio_entities/BE0000599
    TargetHumans

    production and cause mitochondrial thermogenesis (By similarity). … In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (PubMed:31883789).

    Synonyms: ANT 1
  3. Target

    4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase

    go.drugbank.com/bio_entities/BE0004121
    TargetMycobacterium tuberculosis

    Catalyzes the hydrolysis of a carbon-carbon bond in 4,5: 9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate (4,9-DSHA) to yield 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oate (DOHNAA) and … Is also able to catalyze the hydrolysis of 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid (HOPDA) and the synthetic analog 8-(2-chlorophenyl)-2-hydroxy-5-methyl-6-oxoocta-2,4-dienoic acid (HOPODA).

    Synonyms: Meta-cleavage product hydrolase
  4. Target

    Calpain-2 catalytic subunit

    go.drugbank.com/bio_entities/BE0012693
    TargetHumans

    Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.

    Synonyms: CANP 2
  5. Target

    Calpain small subunit 1

    go.drugbank.com/bio_entities/BE0004144
    TargetHumans

    Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.

    Synonyms: CANP small subunit
  6. Target

    Calpain-3

    go.drugbank.com/bio_entities/BE0003470
    TargetHumans

    Calcium-regulated non-lysosomal thiol-protease. Proteolytically cleaves CTBP1 at 'His-409'. Mediates, with UTP25, the proteasome-independent degradation of p53/TP53 (PubMed:23357851, PubMed:27657329)

    Synonyms: CANP 3
  7. Target

    Calpain-1 catalytic subunit

    go.drugbank.com/bio_entities/BE0003346
    TargetHumans

    Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-387' and 'His-409' (PubMed:23707407). Cleaves and activates caspase-7 (CASP7) (PubMed:19617626) … Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction (PubMed:19617626, PubMed:21531719, PubMed:2400579

    Synonyms: CANP 1