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Displaying results 161 - 170 of 176 in total
  1. Target

    Melanoma antigen preferentially expressed in tumors

    go.drugbank.com/bio_entities/BE0010493
    TargetHumans

    and apoptosis (PubMed:16179254) … In the nucleus, the CRL2(PRAME) complex is recruited to epigenetically and transcriptionally active promoter regions bound by nuclear transcription factor Y (NFY) and probably plays a role in chromstin

    Synonyms: OIP-4
  2. Target

    Homeodomain-interacting protein kinase 3

    go.drugbank.com/bio_entities/BE0009448
    TargetHumans

    Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2.

    Synonyms: FIST
  3. Target

    Angiopoietin-2

    go.drugbank.com/bio_entities/BE0010028
    TargetHumans

    Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling (PubMed:15284220, PubMed:19116766, PubMed:19223473, PubMed:9204896). … In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (PubMed:15284220, PubMed:19116766, PubMed:19223473, PubMed:9204896).

    Synonyms: ANG-2
  4. Target

    Angiopoietin-1

    go.drugbank.com/bio_entities/BE0010681
    TargetHumans

    Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. … kinase and the AKT1 signaling cascades.

    Synonyms: ANG-1
  5. Target

    Pyruvate kinase PKM

    go.drugbank.com/bio_entities/BE0000088
    TargetHumans

    The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723, PubMed:20847263) … The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed

    Synonyms: OIP-3
  6. Target

    Aminoglycoside nucleotidyltransferase (4')

    go.drugbank.com/bio_entities/BE0003547
    EnzymeStaphylococcus aureus

    Inactivates the antibiotic kanamycin by catalyzing the transfer of a nucleotidyl group from nucleoside triphosphates such as ATP to the 4'-hydroxyl group of the aminoglycoside.

    Synonyms: ANT(4')
  7. Target

    Angiopoietin-related protein 3

    go.drugbank.com/bio_entities/BE0010034
    TargetHumans

    The inhibition of LPL activity appears to be an indirect mechanism involving recruitment of proprotein convertases PCSK6 and FURIN to LPL leading to cleavage and dissociation of LPL from the cell surface … Can bind to adipocytes to activate lipolysis, releasing free fatty acids and glycerol (PubMed:12565906).

    Synonyms: ANG-5
  8. Target

    Natriuretic peptides B

    go.drugbank.com/bio_entities/BE0000979
    TargetHumans

    Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion (PubMed … Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses (PubMed:1672777, PubMed:17349887, PubMed:17372040, PubMed

    Synonyms: Iso-ANP
  9. Target

    ADP/ATP translocase 3

    go.drugbank.com/bio_entities/BE0000624
    TargetHumans

    production and cause mitochondrial thermogenesis (By similarity). … ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity).

    Synonyms: ANT 2, ANT 3
  10. Target

    Eph receptors

    go.drugbank.com/bio_entities/BE0028186
    TargetHumans

    Binds to EFNA3, EFNA4 and EFNA5 … Generally has an overlapping and redundant function with EPHB2.

    Synonyms: EPH- and ELK-related kinase