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Displaying results 161 - 170 of 204 in total
  1. Target

    4-diphosphocytidyl-2-C-methyl-D-erythritol kinase

    go.drugbank.com/bio_entities/BE0001574
    TargetShigella flexneri

    Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

    Polypeptides: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinaseSynonyms: 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase
  2. Target

    Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase

    go.drugbank.com/bio_entities/BE0001689
    TargetMycobacterium tuberculosis

    Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions … Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate.

    Polypeptides: Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolaseFunction: 4-hydroxy-4-methyl-2-oxoglutarate aldolase activity
  3. Target

    D-galactose/methyl-galactoside binding periplasmic protein MglB

    go.drugbank.com/bio_entities/BE0002058
    TargetTransporterEscherichia coli (strain K12)

    In addition, binds D-galactose and D-glucose and plays a role in the chemotaxis towards these two sugars by interacting with the Trg chemoreceptor (PubMed:3057628, PubMed:4927373). … Part of the ABC transporter complex MglABC involved in galactose/methyl galactoside import (Probable).

    Polypeptides: D-galactose/methyl-galactoside binding periplasmic protein MglB
  4. Target

    2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

    go.drugbank.com/bio_entities/BE0004106
    TargetEscherichia coli (strain K12)

    Also converts 4-diphosphocytidyl-2-C-methyl-D-erythritol into 2-C-methyl-D-erythritol 3,4-cyclophosphate and CMP. … Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.

    Polypeptides: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthaseFunction: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
  5. Target

    Aurora kinase A

    go.drugbank.com/bio_entities/BE0000991
    TargetHumans

    Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (PubMed:27335426). … Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome

    Synonyms: Ipl1- and aurora-related kinase 1
  6. Target

    E3 ubiquitin-protein ligase HUWE1

    go.drugbank.com/bio_entities/BE0016469
    TargetHumans

    Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). … Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956).

    Synonyms: HECT, UBA and WWE domain-containing protein 1
  7. Target

    NADPH oxidase

    go.drugbank.com/bio_entities/BE0004904
    TargetHumans

    efficiency in chemokine uptake and degradation. … Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity (PubMed:9121475).

    Synonyms: SH3 and PX domain-containing protein 1A, SH3 and PX domain-containing protein 4
  8. Target

    Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

    go.drugbank.com/bio_entities/BE0003739
    TargetHumans

    Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner (PubMed:17828269). … Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation.

    Synonyms: PPIase Pin1, Rotamase Pin1
  9. Target

    Melanoma antigen preferentially expressed in tumors

    go.drugbank.com/bio_entities/BE0010493
    TargetHumans

    and apoptosis (PubMed:16179254) … In the nucleus, the CRL2(PRAME) complex is recruited to epigenetically and transcriptionally active promoter regions bound by nuclear transcription factor Y (NFY) and probably plays a role in chromstin

    Synonyms: OIP-4
  10. Target

    Angiopoietin-2

    go.drugbank.com/bio_entities/BE0010028
    TargetHumans

    Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling (PubMed:15284220, PubMed:19116766, PubMed:19223473, PubMed:9204896). … In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (PubMed:15284220, PubMed:19116766, PubMed:19223473, PubMed:9204896).

    Synonyms: ANG-2