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Displaying results 161 - 170 of 178 in total
  1. Target

    Phosphatidylinositol 5-phosphate 4-kinase type-2 beta

    go.drugbank.com/bio_entities/BE0009517
    TargetHumans

    PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. … They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed:31091439)

  2. Target

    Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

    go.drugbank.com/bio_entities/BE0009518
    TargetHumans

    PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. … They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed:31091439)

  3. Target

    Transient receptor potential cation channel subfamily M member 4

    go.drugbank.com/bio_entities/BE0009748
    TargetHumans

    Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload.

  4. Target

    Receptor for retinol uptake STRA6

    go.drugbank.com/bio_entities/BE0009879
    TransporterHumans

    transport and LRAT-dependent generation of retinol metabolites that then trigger activation of JAK2 and its target STAT5, and ultimately increase the expression of SOCS3 and inhibit cellular responses to insulin

  5. Target

    Proton-coupled zinc antiporter SLC30A8

    go.drugbank.com/bio_entities/BE0009896
    TransporterHumans

    Proton-coupled zinc ion antiporter mediating the entry of zinc into the lumen of pancreatic beta cell secretory granules, thereby regulating insulin secretion

  6. Target

    Metal cation symporter ZIP14

    go.drugbank.com/bio_entities/BE0009903
    TransporterHumans

    Regulates insulin receptor signaling, glucose uptake, glycogen synthesis and gluconeogenesis in hepatocytes through the zinc-dependent intracellular catabolism of insulin (PubMed:27703010).

  7. Target

    Plasma membrane calcium-transporting ATPase

    go.drugbank.com/bio_entities/BE0009972
    TargetHumans

    Regulates insulin sensitivity through calcium/calmodulin signaling pathway by regulating AKT1 activation and NOS3 activation in endothelial cells (PubMed:29104511).

  8. Target

    Calcium transporting ATPases

    go.drugbank.com/bio_entities/BE0010002
    TargetHumans

    Regulates insulin sensitivity through calcium/calmodulin signaling pathway by regulating AKT1 activation and NOS3 activation in endothelial cells (PubMed:29104511).

  9. Target

    Somatostatin receptor

    go.drugbank.com/bio_entities/BE0010250
    TargetHumans

    Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization

  10. Target

    Ribosomal protein S6 kinase beta-1

    go.drugbank.com/bio_entities/BE0010424
    TargetHumans

    Mediates TNF-induced insulin resistance by phosphorylating IRS1 at multiple serine residues, resulting in accelerated degradation of IRS1 (PubMed:18952604).