Search
Methadone
go.drugbank.com/drugs/DB00333ApprovedInvestigational[A183995] Overall, methadone's pharmacological actions result in analgesia, suppression of opioid withdrawal symptoms, sedation, miosis, sweating, hypotension, bradycardia, nausea and vomiting (via … binding within the chemoreceptor trigger zone), and constipation.
Categories: NMDA Receptor AntagonistsProtein arginine N-methyltransferase 1
go.drugbank.com/bio_entities/BE0004597TargetHumansMay be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator
Synonyms: Interferon receptor 1-bound protein 4Stabilin-2
go.drugbank.com/bio_entities/BE0004948TargetHumansPhosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). … Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature.
Synonyms: Hyaluronan receptor for endocytosis, Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2Integrin alpha-5
go.drugbank.com/bio_entities/BE0008988TargetHumansITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 … ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430).
Synonyms: Fibronectin receptor subunit alphaEphrin-B2
go.drugbank.com/bio_entities/BE0010647TargetHumansBinds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. … The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling.
Synonyms: EPH-related receptor tyrosine kinase ligand 5Function: ephrin receptor bindingC-type lectin domain family 12 member A
go.drugbank.com/bio_entities/BE0010945TargetHumansAlso recognizes dead cells by acting as a receptor for monosodium urate crystals, leading to down-regulate neutrophil activation (PubMed:38367667, PubMed:38386511). … Also acts as a pattern-recognition receptor for pathogen-associated molecules, such as plasmodium hemozoin or mycobacterial micolic acid (PubMed:31269448, PubMed:36542980).
Synonyms: Killer cell C-type lectin-like receptor L1, Myeloid inhibitory C-type lectin-like receptorFunction: pattern recognition receptor activityRosuvastatin
go.drugbank.com/drugs/DB01098ApprovedInvestigationalRosuvastatin is also a unique member of the class of statins due to its high hydrophilicity which increases hepatic uptake at the site of action, low bioavailability, and minimal metabolism via the Cytochrome
Doxofylline
go.drugbank.com/drugs/DB09273InvestigationalDoxofylline is a methylxanthine derivative with the presence of a dioxolane group in position 7. As a drug used in the treatment of asthma, doxofylline has shown similar efficacy to theophylline but with significantly fewer side effects ...
Categories: Adrenergic beta-2 Receptor AgonistsIntegrin beta-2
go.drugbank.com/bio_entities/BE0001041TargetHumansIntegrin ITGAM:ITGB2 is also a receptor for factor X. Integrin ITGAD:ITGB2 is a receptor for ICAM3 and VCAM1 (PubMed:10438935, PubMed:8777714, PubMed:9841932). … Integrin ITGAM:ITGB2/MAC-1 complex functions as a signaling receptor for the ligand receptor ICAM1, ensuring adhesion between stimulated neutrophils and stimulated endothelial cells (PubMed:1980124).
Synonyms: Complement receptor C3 subunit betaSialic acid-binding Ig-like lectin 7
go.drugbank.com/bio_entities/BE0001648TargetHumansIn the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through
Synonyms: Adhesion inhibitory receptor molecule 1