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Heat shock protein 75 kDa, mitochondrial
go.drugbank.com/bio_entities/BE0014134TargetHumansChaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the bala...
Synonyms: Tumor necrosis factor type 1 receptor-associated proteinLysosome membrane protein 2
go.drugbank.com/bio_entities/BE0014604TransporterHumansActs as a lysosomal receptor for glucosylceramidase (GBA1) targeting
Synonyms: Scavenger receptor class B member 2Function: cargo receptor activityCytohesin-3
go.drugbank.com/bio_entities/BE0004433TargetHumansPromotes guanine-nucleotide exchange on ARF1 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays a role in the epithelial polarization (By similarity)
Synonyms: General receptor of phosphoinositides 1Elongation factor 1-alpha 1
go.drugbank.com/bio_entities/BE0004528TargetHumansTranslation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:362...
Synonyms: Leukocyte receptor cluster member 7C-type lectin domain family 7 member A
go.drugbank.com/bio_entities/BE0019143TargetHumansLectin that functions as a pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi (PubMed … Necessary for the TLR2-mediated inflammatory response and activation of NF-kappa-B: upon beta-glucan binding, recruits SYK via its ITAM motif and promotes a signaling cascade that activates some CARD domain-BCL10
Synonyms: Beta-glucan receptorCOUP transcription factor 1
go.drugbank.com/bio_entities/BE0008953TargetHumansCoup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and palindromes of th...
Synonyms: Nuclear receptor subfamily 2 group F member 1Retinoic acid-induced protein 3
go.drugbank.com/bio_entities/BE0000697TargetHumansOrphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells.
Synonyms: G protein-coupled receptor family C group 5 member AVLA-4 (very late antigen-4)
go.drugbank.com/bio_entities/BE0010014TargetHumansIntegrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. … Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1.
Synonyms: Fibronectin receptor subunit betaNACHT, LRR and PYD domains-containing protein 3
go.drugbank.com/bio_entities/BE0010347TargetHumansSensor component of the NLRP3 inflammasome, which mediates inflammasome activation in response to defects in membrane integrity, leading to secretion of inflammatory cytokines IL1B and IL18 and pyroptosis (PubMed:16407889, PubMed:1840367...
Synonyms: Angiotensin/vasopressin receptor AII/AVP-likeKinesin-like protein KIF11
go.drugbank.com/bio_entities/BE0001852TargetHumansMotor protein required for establishing a bipolar spindle and thus contributing to chromosome congression during mitosis (PubMed:19001501, PubMed:37728657). Required in non-mitotic cells for transport of secretory proteins from the Golgi...
Synonyms: Thyroid receptor-interacting protein 5