Search
Acute Intermittent Porphyria
smpdb.ca/view/SMP0000344DiseaseSymptoms of the disorder include abdominal pain, constipation, vomiting, hypertension, muscle weakness, seizures, delirium, coma, and depression. … Treatment involves undertaking a high-carbohydrate diet and, during severe attacks, a glucose 10% infusion. It is estimated that AIP affects 5.9 per 1 000 000 people.
Enzymes: Uroporphyrinogen-III synthase, Coproporphyrinogen-III oxidase, mitochondrialPorphyria Variegata (PV)
smpdb.ca/view/SMP0000346DiseaseA defect in this enzyme results in the build up of several compounds, including porphobilinogen, 5-aminolevulinic acid, and in feces and urine, porphyrin and coproporphyrin. … Indeed, the skin sensitivity can be so extreme that skin pigmentation changes, scarring and blistering and even hair growth can ensue on exposed areas.
Enzymes: Uroporphyrinogen-III synthase, Coproporphyrinogen-III oxidase, mitochondrialSelenoamino Acid Metabolism
smpdb.ca/view/SMP0000029MetabolicThese 2 products combine to produce a cardiolipin and an ethanolamine. The L-1 phosphatidyl-glycerol can also interact with cardiolipin synthase resulting in a glycerol and a cardiolipin. … The major phospholipids of P. aeruginosa are phosphatidylethanolamine, phosphatidylglycerol, and cardiolipin.
Enzymes: Selenide, water dikinase 2Acute Intermittent Porphyria
smpdb.ca/view/SMP0125644DiseaseSymptoms of the disorder include abdominal pain, constipation, vomiting, hypertension, muscle weakness, seizures, delirium, coma, and depression. … Treatment involves undertaking a high-carbohydrate diet and, during severe attacks, a glucose 10% infusion. It is estimated that AIP affects 5.9 per 1 000 000 people.
Enzymes: Uroporphyrinogen-III synthase, Coproporphyrinogen-III oxidase, mitochondrialHereditary Coproporphyria (HCP)
smpdb.ca/view/SMP0000342DiseaseThis gene is responsible for mitochondrial coproporphyrinogen-III oxidase. … from alcohol and drug use.
Enzymes: Uroporphyrinogen-III synthase, Coproporphyrinogen-III oxidase, mitochondrialCongenital Erythropoietic Porphyria (CEP) or Gunther Disease
smpdb.ca/view/SMP0000345DiseaseThis enzyme catalyzes the dehydrogenation of hydroxymethylbilane into water and uroporphyrinogen III, which will undergo several more reactions to eventually form heme. … Red urine and teeth can also be seen in infancy.
Enzymes: Uroporphyrinogen-III synthase, Coproporphyrinogen-III oxidase, mitochondrialPorphyria Variegata (PV)
smpdb.ca/view/SMP0125649DiseaseA defect in this enzyme results in the build up of several compounds, including porphobilinogen, 5-aminolevulinic acid, and in feces and urine, porphyrin and coproporphyrin. … Indeed, the skin sensitivity can be so extreme that skin pigmentation changes, scarring and blistering and even hair growth can ensue on exposed areas.
Enzymes: Uroporphyrinogen-III synthase, Coproporphyrinogen-III oxidase, mitochondrialCongenital Erythropoietic Porphyria (CEP) or Gunther Disease
smpdb.ca/view/SMP0125650DiseaseThis enzyme catalyzes the dehydrogenation of hydroxymethylbilane into water and uroporphyrinogen III, which will undergo several more reactions to eventually form heme. … Red urine and teeth can also be seen in infancy.
Enzymes: Uroporphyrinogen-III synthase, Coproporphyrinogen-III oxidase, mitochondrialHereditary Coproporphyria (HCP)
smpdb.ca/view/SMP0125651DiseaseThis gene is responsible for mitochondrial coproporphyrinogen-III oxidase. … from alcohol and drug use.
Enzymes: Uroporphyrinogen-III synthase, Coproporphyrinogen-III oxidase, mitochondrialTriflusal Action Pathway
smpdb.ca/view/SMP0126548Drug actionIt is indicated as prophylaxis of thromboembolic disorders (prevention of strokes and myocardial infarction). … It also acts on many other cellular targets like NF kappa B, which is a gene expression regulatory factor for cycloxygenase-a and cytokines.
Enzymes: Integrin alpha-IIb