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Displaying results 171 - 180 of 184 in total
  1. Target

    E3 ubiquitin-protein ligase HUWE1

    go.drugbank.com/bio_entities/BE0016469
    TargetHumans

    Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). … Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956).

    Synonyms: HECT, UBA and WWE domain-containing protein 1
  2. Target

    NADPH oxidase

    go.drugbank.com/bio_entities/BE0004904
    TargetHumans

    efficiency in chemokine uptake and degradation. … Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity (PubMed:9121475).

    Synonyms: SH3 and PX domain-containing protein 4, SH3 and PX domain-containing protein 1A
  3. Target

    Angiopoietin-2

    go.drugbank.com/bio_entities/BE0010028
    TargetHumans

    Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling (PubMed:15284220, PubMed:19116766, PubMed:19223473, PubMed:9204896). … In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (PubMed:15284220, PubMed:19116766, PubMed:19223473, PubMed:9204896).

    Synonyms: ANG-2
  4. Target

    Angiopoietin-1

    go.drugbank.com/bio_entities/BE0010681
    TargetHumans

    Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. … kinase and the AKT1 signaling cascades.

    Synonyms: ANG-1
  5. Target

    Aminoglycoside nucleotidyltransferase (4')

    go.drugbank.com/bio_entities/BE0003547
    EnzymeStaphylococcus aureus

    Inactivates the antibiotic kanamycin by catalyzing the transfer of a nucleotidyl group from nucleoside triphosphates such as ATP to the 4'-hydroxyl group of the aminoglycoside.

    Synonyms: ANT(4')
  6. Target

    Angiopoietin-related protein 3

    go.drugbank.com/bio_entities/BE0010034
    TargetHumans

    The inhibition of LPL activity appears to be an indirect mechanism involving recruitment of proprotein convertases PCSK6 and FURIN to LPL leading to cleavage and dissociation of LPL from the cell surface … Can bind to adipocytes to activate lipolysis, releasing free fatty acids and glycerol (PubMed:12565906).

    Synonyms: ANG-5
  7. Target

    Natriuretic peptides B

    go.drugbank.com/bio_entities/BE0000979
    TargetHumans

    Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion (PubMed … Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses (PubMed:1672777, PubMed:17349887, PubMed:17372040, PubMed

    Synonyms: Iso-ANP
  8. Target

    ADP/ATP translocase 3

    go.drugbank.com/bio_entities/BE0000624
    TargetHumans

    production and cause mitochondrial thermogenesis (By similarity). … ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity).

    Synonyms: ANT 2, ANT 3
  9. Target

    Eph receptors

    go.drugbank.com/bio_entities/BE0028186
    TargetHumans

    Binds to EFNA3, EFNA4 and EFNA5 … Generally has an overlapping and redundant function with EPHB2.

    Synonyms: EPH- and ELK-related kinase
  10. Target

    Atrial natriuretic peptide receptor 1

    go.drugbank.com/bio_entities/BE0000556
    TargetHumans

    and subsequently PRKAA1, thereby controlling blood pressure and maintaining cardiovascular homeostasis (PubMed:36016499) … Plays an essential role in the regulation of endothelial cell senescence and vascular aging (PubMed:36016499).

    Synonyms: ANP-A