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Kidney Function - Distal Convoluted Tubule
smpdb.ca/view/SMP0121012PhysiologicalAs a result, a high concentration of sodium, chlorine, and calcium in the blood vessels occurs. The reabsorption of ions and water increases blood fluid volume and blood pressure. … In addition, sodium, chlorine, and calcium are also reabsorbed back into the systemic circulation via their respective channels and exchangers.
Enzymes: Chloride channel protein ClC-KaCastor Oil Action Pathway
smpdb.ca/view/SMP0174887Drug actionCastor Oil may also promote ulcer healing by increasing mucus and bicarbonate secretion and thickening the mucosal bilayer so the mucosa can generate new cells. … With reduced protein kinase A activation, this decreases the activity of the proton pump, fewer H+ ions are pumped into the lumen, reducing the acidity and thus allowing stomach ulcers to heal and reducing
Drugs: ATP · Potassium cation · Magnesium cation · Zinc · Cyclic adenosine monophosphate · Pyrophosphoric acid +1 moreEnzymes: Chloride anion exchangerLatanoprostene bunod Action Pathway
smpdb.ca/view/SMP0175202Drug actionLatanoprostene bunod may also promote ulcer healing by increasing mucus and bicarbonate secretion and thickening the mucosal bilayer so the mucosa can generate new cells. … With reduced protein kinase A activation, this decreases the activity of the proton pump, fewer H+ ions are pumped into the lumen, reducing the acidity and thus allowing stomach ulcers to heal and reducing
Drugs: ATP · Potassium cation · Magnesium cation · Zinc · Cyclic adenosine monophosphate · Pyrophosphoric acid +1 moreEnzymes: Chloride anion exchangerQuinethazone Action Pathway
smpdb.ca/view/SMP0123030Drug actionNa+ into the cell and Ca2+ into the interstitium-blood; and the chloride transporter which transports chloride into the interstitium-blood. … In the distal convoluted tubule (DCT), the regulation of ions such as sodium, potassium, calcium, chloride, and magnesium occurs.
Enzymes: Chloride channel protein ClC-KaIndapamide Diuretic Action Pathway
smpdb.ca/view/SMP0123031Drug actionNa+ into the cell and Ca2+ into the interstitium-blood; and the chloride transporter which transports chloride into the interstitium-blood. … In the distal convoluted tubule (DCT), the regulation of ions such as sodium, potassium, calcium, chloride, and magnesium occurs.
Enzymes: Chloride channel protein ClC-KaRanitidine H2 Anti-Histamine Action Pathway
smpdb.ca/view/SMP0122729Drug actionRanitidine is an histamine H2 receptor antagonist used to treat stomach ulcers and Gastroesophageal Reflux Disease (GERD). … After being taken orally, it is absorbed in the GI tract and travels through the blood to get to the stomach epithelium.
Drugs: ATP · Ranitidine · Potassium cation · Magnesium cation · Zinc · Cyclic adenosine monophosphateEnzymes: Chloride anion exchangerCimetidine H2 Anti-Histamine Action Pathway
smpdb.ca/view/SMP0123152Drug actionCimetidine is an H2 receptor antagonist drug that is mainly used to treat peptic ulcers and heartburns. … It works by acting as a competitive inhibitor and blocks the action of histamine on Histamine H2 receptors.
Drugs: ATP · Cimetidine · Potassium cation · Magnesium cation · Zinc · Cyclic adenosine monophosphateEnzymes: Chloride anion exchangerFamotidine H2 Anti-Histamine Action Pathway
smpdb.ca/view/SMP0126789Drug actionFamotidine inhibits both basal and nocturnal gastric acid secretion, as well as acid secretion stimulated by food, caffeine, insulin, and pentagastrin. … Famotidine is a histamine H2 receptor antagonist used to treat gastroesophageal reflux disease and various ulcers.
Drugs: ATP · Famotidine · Potassium cation · Magnesium cation · Zinc · Cyclic adenosine monophosphateEnzymes: Chloride anion exchangerMetiamide H2 Anti-Histamine Action Pathway
smpdb.ca/view/SMP0123167Drug actionMetiamide is an histamine H2 receptor antagonist used to treat stomach ulcers and Gastroesophageal Reflux Disease (GERD). … After being taken orally, it is absorbed in the GI tract and travels through the blood to get to the stomach epithelium.
Drugs: ATP · Potassium cation · Magnesium cation · Zinc · Cyclic adenosine monophosphate · MetiamideEnzymes: Chloride anion exchangerRoxatidine Acetate H2 Anti-Histamine Action Pathway
smpdb.ca/view/SMP0123168Drug actionRoxatidine Acetate is an histamine H2 receptor antagonist used to treat stomach ulcers and Gastroesophageal Reflux Disease (GERD). … After being taken orally, it is absorbed in the GI tract and travels through the blood to get to the stomach epithelium.
Drugs: ATP · Potassium cation · Magnesium cation · Zinc · Cyclic adenosine monophosphate · Roxatidine acetateEnzymes: Chloride anion exchanger