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Aminoglycoside nucleotidyltransferase (4')
go.drugbank.com/bio_entities/BE0003547EnzymeStaphylococcus aureusInactivates the antibiotic kanamycin by catalyzing the transfer of a nucleotidyl group from nucleoside triphosphates such as ATP to the 4'-hydroxyl group of the aminoglycoside.
Synonyms: ANT(4')Angiopoietin-related protein 3
go.drugbank.com/bio_entities/BE0010034TargetHumansThe inhibition of LPL activity appears to be an indirect mechanism involving recruitment of proprotein convertases PCSK6 and FURIN to LPL leading to cleavage and dissociation of LPL from the cell surface … Can bind to adipocytes to activate lipolysis, releasing free fatty acids and glycerol (PubMed:12565906).
Synonyms: ANG-5Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
go.drugbank.com/bio_entities/BE0004448TargetHumansGTPase component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons UAA, UAG and UGA (PubMed:15987998, PubMed:19417105, … Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes (PubMed:30682371)
Synonyms: G1 to S phase transition protein 1 homologMitogen-activated protein kinase kinase kinase kinase 5
go.drugbank.com/bio_entities/BE0009474TargetHumansMay play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway
Synonyms: Kinase homologous to SPS1/STE20Natriuretic peptides B
go.drugbank.com/bio_entities/BE0000979TargetHumansActs by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses (PubMed:1672777, PubMed:17349887, PubMed:17372040, PubMed … Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion (PubMed
Synonyms: Iso-ANPADP/ATP translocase 3
go.drugbank.com/bio_entities/BE0000624TargetHumansAlso plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death (PubMed:15033708). … ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity).
Synonyms: ANT 2, ANT 3Eph receptors
go.drugbank.com/bio_entities/BE0028186TargetHumansInvolved in the maintenance of the pool of satellite cells (muscle stem cells) by promoting their self-renewal and reducing their activation and differentiation (By similarity) … Binds to EFNA3, EFNA4 and EFNA5
Synonyms: EPH- and ELK-related kinaseAtrial natriuretic peptide receptor 1
go.drugbank.com/bio_entities/BE0000556TargetHumansand subsequently PRKAA1, thereby controlling blood pressure and maintaining cardiovascular homeostasis (PubMed:36016499) … Plays an essential role in the regulation of endothelial cell senescence and vascular aging (PubMed:36016499).
Synonyms: ANP-AAtrial natriuretic peptide receptor 2
go.drugbank.com/bio_entities/BE0000997TargetHumansReceptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth
Synonyms: ANP-BNucleotide triphosphate diphosphatase NUDT15
go.drugbank.com/bio_entities/BE0009809EnzymeHumansCatalyzes the hydrolysis of nucleoside triphosphates including dGTP, dTTP, dCTP, their oxidized forms like 8-oxo-dGTP and the prodrug thiopurine derivatives 6-thio-dGTP and 6-thio-GTP (PubMed:26238318) … Therefore, the potential in vivo sanitizing role of this enzyme, that would consist in removing oxidatively damaged forms of nucleosides to prevent their incorporation into DNA, is unclear (PubMed:22556419
Synonyms: Nucleoside diphosphate-linked to another moiety X hydrolase 15