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Angiopoietin-1
go.drugbank.com/bio_entities/BE0010681TargetHumansBinds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. … kinase and the AKT1 signaling cascades.
Synonyms: ANG-1Pyruvate kinase PKM
go.drugbank.com/bio_entities/BE0000088TargetHumansThe transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723, PubMed:20847263) … The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production (PubMed
Synonyms: OIP-3Aminoglycoside nucleotidyltransferase (4')
go.drugbank.com/bio_entities/BE0003547EnzymeStaphylococcus aureusInactivates the antibiotic kanamycin by catalyzing the transfer of a nucleotidyl group from nucleoside triphosphates such as ATP to the 4'-hydroxyl group of the aminoglycoside.
Synonyms: ANT(4')Angiopoietin-related protein 3
go.drugbank.com/bio_entities/BE0010034TargetHumansThe inhibition of LPL activity appears to be an indirect mechanism involving recruitment of proprotein convertases PCSK6 and FURIN to LPL leading to cleavage and dissociation of LPL from the cell surface … Can bind to adipocytes to activate lipolysis, releasing free fatty acids and glycerol (PubMed:12565906).
Synonyms: ANG-5Natriuretic peptides B
go.drugbank.com/bio_entities/BE0000979TargetHumansInvolved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion (PubMed … Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses (PubMed:1672777, PubMed:17349887, PubMed:17372040, PubMed
Synonyms: Iso-ANPADP/ATP translocase 3
go.drugbank.com/bio_entities/BE0000624TargetHumansproduction and cause mitochondrial thermogenesis (By similarity). … ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity).
Synonyms: ANT 2, ANT 3Glutamate receptor ionotropic, NMDA 3B
go.drugbank.com/bio_entities/BE0000534TargetHumansComponent of a non-conventional N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with low calcium permeability and low voltage-dependent block … Forms glutamatergic receptor complexes with GluN1 and GluN2 subunits which are activated by glycine binding to the GluN1 and GluN3 subunits and L-glutamate binding to GluN2 subunits (By similarity).
Synonyms: N-methyl-D-aspartate receptor subtype 3BAdenosine deaminase
go.drugbank.com/bio_entities/BE0009226TargetPlasmodium falciparum (isolate 3D7)Plays an essential role in the purine salvage pathway which allows the parasite to use host cell purines for the synthesis of nucleic acids (Probable).
Synonyms: S-methyl-5'-thioadenosine deaminaseGlutamate receptor ionotropic, NMDA 2B
go.drugbank.com/bio_entities/BE0000417TargetHumansComponent of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed: … NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium (By similarity).
Synonyms: N-methyl D-aspartate receptor subtype 2B, N-methyl-D-aspartate receptor subunit 3Eph receptors
go.drugbank.com/bio_entities/BE0028186TargetHumansBinds to EFNA3, EFNA4 and EFNA5 … Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC.
Synonyms: EPH- and ELK-related kinase