Search
Methyldopa Action Pathway
smpdb.ca/view/SMP0125087Drug actionLow concentration of calcium prevents the release of norepinephrine into the synapse.
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Sapropterin · Norepinephrine · Dopamine +5 moreTrimipramine Action Pathway
smpdb.ca/view/SMP0126348Drug actionTrimipramine acts by decreasing the reuptake of norepinephrine and serotonin (5-HT) in the neurons.
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Tryptophan · Sapropterin · Norepinephrine +7 moreDexmedetomidine
go.drugbank.com/drugs/DB00633ApprovedInvestigationalVet approvedAn agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.
Codeine Action Pathway
smpdb.ca/view/SMP0000405Drug actionOpiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for...
Citalopram Action Pathway
smpdb.ca/view/SMP0000424Drug actionCitalopram is a selective serotonin reuptake inhibitor that exerts antidepressive effects by selectively inhibiting serotonin reuptake in the brain. It does so by competing for the same binding site as serotonin on the the sodium-depende...
Imipramine Action Pathway (New)
smpdb.ca/view/SMP0126359Drug actionImipramine binds to the sodium-dependent serotonin transporter and to the sodium-dependent norepinephrine transporter reducing the reuptake of norepinephrine and serotonin by presynaptic neurons. … Depression has been linked to a lack of stimulation of the post-synaptic neuron by norepinephrine and serotonin.
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Tryptophan · Sapropterin · Norepinephrine +7 moreFencamfamin
go.drugbank.com/drugs/DB01463ApprovedIllicitWithdrawnFencamfamin (Glucoenergan, Reactivan) is a stimulant which was developed in the 1960s as an appetite suppressant. It is around half the potency of dexamphetamine, and is prescribed at a dose of 10-60mg, although abusers of the drug tend ...
Nortriptyline Action Pathway
smpdb.ca/view/SMP0126345Drug actionNortriptyline exerts antidepressant functions by inhibiting the reuptake of serotonin and norepinephrine in the neurons.
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Tryptophan · Sapropterin · Norepinephrine +7 moreDesipramine Action Pathway (New)
smpdb.ca/view/SMP0126352Drug actionSecondary amine TCAs, such as desipramine, are more potent inhibitors of norepinephrine reuptake than tertiary amine TCAs.
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Tryptophan · Sapropterin · Norepinephrine +7 moreIsocarboxazid
go.drugbank.com/drugs/DB01247ApprovedIsocarboxazid has the formula 1-benzyl-2-(5-methyl-3-isoxazolylcarbonyl)hydrazine-isocarboxazid. It is a monoamine oxidase inhibitor. It is used in the treatment of major depression, dysthymic disorder, atypical disorder, panic disorder ...