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Displaying results 171 - 180 of 1567 in total
  1. Pathway

    Chloroprocaine Action Pathway

    smpdb.ca/view/SMP0000394
    Drug action

    Chloroprocaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Chloroprocaine diffuses across the neuronal plasma membrane in its uncharged base form. Once inside the cytoplasm, it is ...

    Drugs: ATP · Norepinephrine · Dopamine · Chloroprocaine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  2. Pathway

    Proparacaine Action Pathway

    smpdb.ca/view/SMP0000403
    Drug action

    Proparacaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Proparacaine diffuses across the neuronal plasma membrane in its uncharged base form. Once inside the cytoplasm, it is prot...

    Drugs: ATP · Norepinephrine · Proparacaine · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  3. Pathway

    Remifentanil Action Pathway

    smpdb.ca/view/SMP0000416
    Drug action

    Remifentanil is a pharmacologically-active, synthetic, small molecule derived from fentanyl and belongs to a class of drugs called opioids. Opioids are therapeutically employed to achieve analgesia. Remifentanial’s rapid mechanism of act...

    Drugs: ATP · Norepinephrine · Remifentanil · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  4. Pathway

    Imipramine

    smpdb.ca/view/SMP0000422
    Drug action

    Imipramine is a tricyclic antidepressant that exerts its therapeutic effects by inhibiting norepinephrine and serotonin reuptake in the brain. It does so by competing for the same binding site as norepinephrine on the sodium-dependent no...

    Drugs: NADH · ATP · Norepinephrine · Imipramine · Dopamine · Desipramine +4 more
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  5. Pathway

    Tramadol Action Action Pathway

    smpdb.ca/view/SMP0000671
    Drug action

    Tramadol is an analgesic drug consisting of two enantiomer forms (+)-Tramadol and (-)-Tramadol. Both contribute to pain relief by inhibiting pain transmission in the spinal cord via different mechanisms. (+)-Tramadol is a selective agoni...

    Drugs: ATP · Tramadol · Norepinephrine · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  6. Pathway

    Alvimopan Action Pathway

    smpdb.ca/view/SMP0000685
    Drug action

    Alvimopan is prescribed to treat patient opioid-induced constipation, a common side effect of opioid therapy. This side effect results in delayed discharge for hospitalized patients following surgery. Alvimopan helps to increase gastroin...

    Drugs: ATP · Norepinephrine · Dopamine · Potassium cation · Calcium · Alvimopan
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  7. Pathway

    Naloxone Action Pathway

    smpdb.ca/view/SMP0000688
    Drug action

    Naloxone (also known as Narcan) is a competitive antagonist of mu-type opioid receptor in the central nervous system (CNS). Naloxone is also a type of medication that are used for manage opioid or alcohol dependence. Binding of naloxone ...

    Drugs: ATP · Norepinephrine · Dopamine · Naloxone · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  8. Pathway

    Benzocaine Action Pathway

    smpdb.ca/view/SMP0000392
    Drug action

    Benzocaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Benzocaine diffuses across the neuronal plasma membrane in its uncharged base form. Once inside the cytoplasm, it is protonat...

    Drugs: ATP · Norepinephrine · Dopamine · Benzocaine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  9. Pathway

    Mepivacaine Action Pathway

    smpdb.ca/view/SMP0000399
    Drug action

    Mepivacaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Mepivacaine diffuses across the neuronal plasma membrane in its uncharged base form. Once inside the cytoplasm, it is proton...

    Drugs: ATP · Norepinephrine · Mepivacaine · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  10. Pathway

    Prilocaine Action Pathway

    smpdb.ca/view/SMP0000401
    Drug action

    Prilocaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Prilocaine diffuses across the neuronal plasma membrane in its uncharged base form. Once inside the cytoplasm, it is protonat...

    Drugs: ATP · Norepinephrine · Prilocaine · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1