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NAD-dependent protein deacetylase sirtuin-1
go.drugbank.com/bio_entities/BE0002461TargetHumansProposed to deacetylate IRS2 thereby facilitating its insulin-induced tyrosine phosphorylation. … Involved in positive regulation of insulin secretion in pancreatic beta cells in response to glucose; the function seems to imply transcriptional repression of UCP2.
Pituitary adenylate cyclase-activating polypeptide
go.drugbank.com/bio_entities/BE0003199TargetHumansInvolved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity).
Transitional endoplasmic reticulum ATPase
go.drugbank.com/bio_entities/BE0004572TargetHumansBy controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333)
Potassium voltage-gated channel subfamily B member 1
go.drugbank.com/bio_entities/BE0004721TargetHumansContributes to the regulation of glucose-induced action potential amplitude and duration in pancreatic beta cells, hence limiting calcium influx and insulin secretion (PubMed:23161216). … May confer neuroprotection in response to hypoxia/ischemic insults by suppressing pyramidal neurons hyperexcitability in hippocampal and cortical regions (By similarity).
RalA-binding protein 1
go.drugbank.com/bio_entities/BE0004770TransporterHumansAs part of the Ral signaling pathway, may also regulate ligand-dependent EGF and insulin receptors-mediated endocytosis (PubMed:10910768, PubMed:12775724).
Alpha adrenergic receptor
go.drugbank.com/bio_entities/BE0004888TargetHumansControl a variety of physiological processes, such as regulation of blood pressure, lipolysis and insulin release (PubMed:2164221). … Control a variety of physiological processes, such as regulation of blood pressure, lipolysis and insulin release (PubMed:2842764).
Solute carrier family 2, facilitated glucose transporter member 8
go.drugbank.com/bio_entities/BE0005219TransporterHumansInsulin-regulated facilitative hexose transporter that mediates the transport of glucose and fructose (By similarity).
Ephrin type-A receptor 5
go.drugbank.com/bio_entities/BE0005587TargetHumansIn addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity
Sulfonylurea receptor 1, Kir6.2
go.drugbank.com/bio_entities/BE0008670TargetHumansRegulator subunit of pancreatic ATP-sensitive potassium channel (KATP), playing a major role in the regulation of insulin release.
Heterogeneous nuclear ribonucleoprotein H
go.drugbank.com/bio_entities/BE0008961TargetHumansInhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG)