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Displaying results 1831 - 1840 of 10000 in total
  1. Target

    NACHT, LRR and PYD domains-containing protein 3

    go.drugbank.com/bio_entities/BE0010347
    TargetHumans

    Sensor component of the NLRP3 inflammasome, which mediates inflammasome activation in response to defects in membrane integrity, leading to secretion of inflammatory cytokines IL1B and IL18 and pyroptosis … In response to pathogens and other damage-associated signals that affect the integrity of membranes, initiates the formation of the inflammasome polymeric complex composed of NLRP3, CASP1 and PYCARD/ASC

    Polypeptides: NACHT, LRR and PYD domains-containing protein 3
  2. Target

    Zinc finger and BTB domain-containing protein 7A

    go.drugbank.com/bio_entities/BE0012406
    TargetHumans

    Directly and specifically binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' and represses transcription both by regulating the organization of chromatin and through the direct recruitment of transcription … Plays a key role in the differentiation of lymphoid progenitors into B and T lineages (By similarity).

    Polypeptides: Zinc finger and BTB domain-containing protein 7ASynonyms: POZ and Krueppel erythroid myeloid ontogenic factor
  3. Target

    A disintegrin and metalloproteinase with thrombospondin motifs 4

    go.drugbank.com/bio_entities/BE0004687
    EnzymeTargetHumans

    May play an important role in the destruction of aggrecan in arthritic diseases. Could be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease … Cleaves aggrecan, a cartilage proteoglycan, at the '392-Glu-|-Ala-393' site and may be involved in its turnover (PubMed:10356395, PubMed:10827174). Also cleaves COMP (PubMed:39672391).

    Polypeptides: A disintegrin and metalloproteinase with thrombospondin motifs 4
  4. Target

    A disintegrin and metalloproteinase with thrombospondin motifs 13

    go.drugbank.com/bio_entities/BE0009336
    EnzymeTargetHumans

    Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation

    Polypeptides: A disintegrin and metalloproteinase with thrombospondin motifs 13
  5. Target

    T-cell immunoreceptor with Ig and ITIM domains

    go.drugbank.com/bio_entities/BE0010742
    TargetHumans

    In turn, inhibits PI3K and MAPK signaling cascades (PubMed:23154388). … In addition, associates with beta-arrestin-2/ARRB2 to recruit SHIP1/INPP5D that suppresses autoubiquitination of TRAF6 and subsequently inhibits NF-kappa-B signaling pathway (PubMed:24817116).

    Polypeptides: T-cell immunoreceptor with Ig and ITIM domainsSynonyms: V-set and immunoglobulin domain-containing protein 9, V-set and transmembrane domain-containing protein 3
  6. Drug

    Dyclonine

    go.drugbank.com/drugs/DB00645
    ApprovedInvestigational

    Dyclonine is an oral anaesthetic found in Sucrets, an over the counter throat lozenge. It may also be found in some Cepacol sore throat spray products.

    Mixtures: Benzethonium Chloride and Dyclonine Hydrochloride, Benzethonium chloride and Dyclonine hydrochlorideSynonyms: 4-n-butoxy-β-(1-piperidyl)propiophenone
  7. Drug

    N-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}-5-methyl-D-tryptophan

    go.drugbank.com/drugs/DB07233
    Experimental

    Synonyms: N-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}-5-methyl-D-tryptophan
  8. Drug

    Chamomile

    go.drugbank.com/drugs/DB14357
    Approved

    Chamomile is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

    Mixtures: Rotosxika Sleep Aid Patch, Zand Calming Herbal LiqProducts: Ethical Herbals Digestive Aid (chamomile Flower Extract)
  9. Drug

    Levodopa

    go.drugbank.com/drugs/DB01235
    ApprovedInvestigational

    Levodopa can be metabolised to dopamine on either side of the blood-brain barrier and so it is generally administered with a dopa decarboxylase inhibitor like carbidopa to prevent metabolism until after … The first developed drug product that was approved by the FDA was a levodopa and carbidopa combined product called Sinemet that was approved on May 2, 1975[A177781,L6133].

    Mixtures: ISICOM 100MG/25MG, ISICOM 100MG/25MGCategories: Dopa and Dopa Derivatives, Amino Acids, Peptides, and Proteins
  10. Drug

    Lurasidone

    go.drugbank.com/drugs/DB08815
    ApprovedInvestigational

    Lurasidone is an atypical antipsychotic developed by Dainippon Sumitomo Pharma. It was approved by the U.S. … Food and Drug Administration (FDA) for treatment of schizophrenia on October 29, 2010 and is currently pending approval for the treatment of bipolar disorder in the United States.

    Products: LATUDA TABLET 20MG, Latuda Film-Coated Tablets 20mg