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Displaying results 1851 - 1860 of 10000 in total
  1. Drug

    RAPA-501-Allo

    go.drugbank.com/drugs/DB15890
    Investigational

    RAPA-501-ALLO is composed of T-cells extracted from healthy volunteers; these cells are then reprogrammed _ex vivo_ in a process that involves de-differentiation and re-differentiation.[L16483]

  2. Pathway

    Acylcarnitine Dec-4-enedioylcarnitine

    smpdb.ca/view/SMP0123874
    Metabolic

    Once in the matrix, dec-4-enedioylcarnitine can react with the carnitine O-palmitoyltransferase 2 enzyme found in the mitochondrial inner membrane to once again form dec-4-enedioyl-CoA and L-carnitine. … In forming an acylcarnitine derivative, dec-4-enedioyl-CoA reacts with L-carnitine to form dec-4-enedioylcarnitine. This reaction is catalyzed by carnitine O-palmitoyltransferase.

    Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 more
  3. Pathway

    Acylcarnitine Dec-3-enedioylcarnitine

    smpdb.ca/view/SMP0123877
    Metabolic

    Once in the matrix, dec-3-enedioylcarnitine can react with the carnitine O-palmitoyltransferase 2 enzyme found in the mitochondrial inner membrane to once again form dec-3-enedioyl-CoA and L-carnitine. … In forming an acylcarnitine derivative, dec-3-enedioyl-CoA reacts with L-carnitine to form dec-3-enedioylcarnitine. This reaction is catalyzed by carnitine O-palmitoyltransferase.

    Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 more
  4. Drug

    Ceritinib

    go.drugbank.com/drugs/DB09063
    ApprovedInvestigational

    The FDA approved ceritinib in April 2014 due to a surprisingly high response rate (56%) towards crizotinib-resistant tumours and has designated it with orphan drug status. … Following treatment with crizotinib (a first-generation ALK inhibitor), most tumours develop drug resistance due to mutations in key "gatekeeper" residues of the enzyme.

    Synonyms: N-{2-[(5-chloro-2-{[2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}propane-2-sulfonamide
  5. Pathway

    Acylcarnitine Dec-5-enedioylcarnitine

    smpdb.ca/view/SMP0123875
    Metabolic

    Once in the matrix, dec-5-enedioylcarnitine can react with the carnitine O-palmitoyltransferase 2 enzyme found in the mitochondrial inner membrane to once again form dec-5-enedioyl-CoA and L-carnitine. … In forming an acylcarnitine derivative, dec-5-enedioyl-CoA reacts with L-carnitine to form dec-5-enedioylcarnitine. This reaction is catalyzed by carnitine O-palmitoyltransferase.

    Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 more
  6. Indication

    Pulmonary Tuberculosis resistant to isoniazid, rifamycins, a fluoroquinolone and a second line injectable antibacterial drug

    go.drugbank.com/conditions/DBCOND0154352
    Drugs: Pretomanid
    Synonyms: Pulmonary Tuberculosis resistant to isoniazid, rifamycins, a fluoroquinolone and a second line injectable antibacterial drug
  7. Drug

    Aluminium phosphate

    go.drugbank.com/drugs/DB14517
    ApprovedInvestigational

    Mixtures: PRIMPERAN GEL
  8. Drug

    Hydralazine

    go.drugbank.com/drugs/DB01275
    ApprovedInvestigational

    [A186820,L8782,L8785] Hydralazine is no longer a first line therapy for these indications since the development of newer antihypertensive medications. … [A186841] Hydralazine is a hydrazine derivative vasodilator used alone or as adjunct therapy in the treatment of hypertension and only as adjunct therapy in the treatment of heart failure.

    Categories: Arteriolar Smooth Muscle, Agents Acting On
  9. Drug

    Dimethyl sulfoxide

    go.drugbank.com/drugs/DB01093
    ApprovedInvestigationalVet approved

    A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. … It is also used to protect tissue during cryopreservation. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.

    Mixtures: Dolobene ratiopharm - GelCategories: Compounds used in a research, industrial, or household setting
  10. Drug

    Meradimate

    go.drugbank.com/drugs/DB11096
    Approved

    Meradimate, before known as menthyl anthranilate, is used in a maximal concentration of 5% in different products as a UV filter. … [T200] It is currently required to be named as meradimate in all FDA approved OTC products. Meradimate is approved by the FDA and Health Canada to be used as an ingredient in sunblocking products.

    Mixtures: BIOCORNEUM PLUS BROAD SPECTRUM SPF 30 ADVANCED SCAR TREATMENT gel, SPF 15 Spray-ON Sunscreen