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Displaying results 1881 - 1890 of 10000 in total
  1. Drug

    Calcium lactate

    go.drugbank.com/drugs/DB13231
    ApprovedVet approved

    It is prepared commercially by the neutralization of lactic acid with calcium carbonate or calcium hydroxide. … Approved by the FDA as a direct food substance affirmed as generally recognized as safe, calcium lactate is used as a firming agent, flavoring agent, leavening agent, stabilizer, and thickener [L2741].

    Mixtures: Calcium Lactate Et Magnesium Sulfate, Cal M TabSynonyms: Calcium 2-hydroxypropanoate (1:2), Hemicalcium L-lactate
  2. Drug

    Triethylenetetramine

    go.drugbank.com/drugs/DB06824
    ApprovedInvestigational

    [A19333] Initially approved by the FDA in 1985 as a second-line treatment for Wilson's disease,[A19334] TETA is currently indicated to treat adults with stable Wilson’s disease who are de-coppered and … tolerant to [penicillamine].

    Categories: Compounds used in a research, industrial, or household setting
  3. Drug

    Palonosetron

    go.drugbank.com/drugs/DB00377
    ApprovedInvestigational

    As of 2008, it is the most recent 5-HT3 antagonist to enter clinical use. … It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first dose of a course of chemotherapy and is the only drug of

    Synonyms: 2-(1-Azabicyclo(2.2.2)oct-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benz(de)isoquinolin-1-one, (3aS)-2-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-oneCategories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Cytochrome P-450 Substrates
  4. Drug

    Oxybuprocaine

    go.drugbank.com/drugs/DB00892
    ApprovedInvestigational

    Oxybuprocaine binds to sodium channels and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions. … Oxybuprocaine (also known as Benoxinate) is a local anesthetic, which is used especially in ophthalmology and otolaryngology.

    Synonyms: 4-Amino-3-butoxy-2-(diethylamino)ethyl ester benzoic acid, 4-Amino-3-butoxy-benzoic acid 2-diethylamino-ethyl esterMixtures: AMIGDAL-B®, BUCALIV® TABLETA MASTICABLE
  5. Drug

    Moexipril

    go.drugbank.com/drugs/DB00691
    ApprovedInvestigational

    Moexipril is a non-sulfhydryl containing precursor of the active angiotensin-converting enzyme (ACE) inhibitor moexiprilat. It is used to treat high blood pressure (hypertension). … It works by relaxing blood vessels, causing them to widen. Lowering high blood pressure helps prevent strokes, heart attacks and kidney problems.

    Categories: Agents Acting on the Renin-Angiotensin System, Heterocyclic Compounds, 2-Ring
  6. Drug

    Tapentadol

    go.drugbank.com/drugs/DB06204
    ApprovedInvestigational

    [L47291] Used in the management of pain, tapentadol is typically reserved for patients who have limited alternative treatment options. … [A260721, A36596] Tapentadol was first approved by the FDA on November 20, 2008. The extended-release formulation of tapentadol was also approved by the FDA on August 26, 2011.

    Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Cytochrome P-450 SubstratesSynonyms: 3-[(1R,2R)-3-(Dimethylamino)-1-ethyl-2-methylpropyl]phenol, PHENOL, 3-((1R,2R)-3-(DIMETHYLAMINO)-1-ETHYL-2-METHYLPROPYL)-
  7. Drug

    Ranitidine

    go.drugbank.com/drugs/DB00863
    ApprovedWithdrawn

    Ranitidine is a commonly used drug, classified as a histamine H2-receptor antagonist, and belongs to the same drug class as [cimetidine] and [famotidine]. … [L10818,F4253] The prevalence of GERD is thought to be 10-20% in western countries.

    Categories: MATE 1 Inhibitors, MATE 2 InhibitorsProducts: RANIDURA T 150MG, RANIDURA T 300MG
  8. Pathway

    Gs Serotonergic Smooth Muscle Contraction

    smpdb.ca/view/SMP0127045
    Physiological

    Serotonergic (5-HT4) receptors are typically coupled to Gs proteins. Activation of Gs proteins stimulates adenylate cyclase (AC), leading to increased production of cyclic AMP (cAMP) from ATP.Gs proteins stimulate adenylate cyclase (AC) ...

    Drugs: ATP · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate · Pyrophosphoric acid
    Enzymes: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
  9. Drug

    Clarithromycin

    go.drugbank.com/drugs/DB01211
    ApprovedInvestigational

    Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. … Clarithromycin may be bacteriostatic or bactericidal depending on the organism and drug concentration.

    Mixtures: HELIPAK 500 + 30 + 1000mg TEDAVİ PAKETİ, 7 TABLETCategories: P-glycoprotein inhibitors, P-glycoprotein substrates
  10. Drug

    Iloperidone

    go.drugbank.com/drugs/DB04946
    ApprovedInvestigational

    Iloperidone is a benzisoxazole [A263557] and an atypical antipsychotic agent that was first approved by the FDA on May 6, 2009. … [A3024] It is considered to be a second-generation antipsychotic drug [A263552] with multiple receptor binding profile, although it shows high affinity towards 5-HT<sub>2A</sub> and dopamine D2 receptors

    Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Cytochrome P-450 SubstratesSynonyms: 1-[4-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1- piperidinyl]propoxy]-3-methoxyphenyl]ethanone, 4'-(3-(4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino)propoxy)-3'-methoxyacetophenone