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Aryl hydrocarbon receptor

Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1 (PubMed:28602820). … Acts as a negative regulator of anti-tumor immunity: indoles and kynurenic acid generated by Trp catabolism act as ligand and activate AHR, thereby promoting AHR-driven cancer cell motility and suppressing

RNA-directed RNA polymerase catalytic subunit

RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments. … During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs.

Cell adhesion molecule CEACAM3

Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an

Cell adhesion molecule CEACAM1

Upon natural killer (NK) cells activation, inhibit KLRK1-mediated cytolysis of CEACAM1-bearing tumor cells by trans-homophilic interactions with CEACAM1 on the target cell and lead to cis-interaction between … CEACAM1 and KLRK1, allowing PTPN6 recruitment and then VAV1 dephosphorylation (PubMed:23696226).

Creatine kinase S-type, mitochondrial

Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). … Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa

Furin

Mediates processing of TGFB1, an essential step in TGF-beta-1 activation (PubMed:7737999).

Fibroblast growth factor 2

Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:8663044). Also acts as an integrin ligand which is required for FGF2 signaling (PubMed:28302677). … Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration (PubMed:28302677, PubMed:8663044).

Oligodendrocyte transcription factor 2

Orchestrates progenitor cell fates during cortical gliogenesis and gliomagenesis. … Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development

Glucanase

Myc proto-oncogene protein

and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808) … Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis (PubMed:24940000, PubMed:25956029).