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Displaying results 181 - 190 of 606 in total
  1. Target

    Insulin-like growth factor 1

    go.drugbank.com/bio_entities/BE0003418
    TargetHumans

    The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. … Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling.

    Polypeptides: Insulin-like growth factor 1Synonyms: Mechano growth factor, Insulin-like growth factor I
  2. Target

    Heat shock factor protein 1

    go.drugbank.com/bio_entities/BE0003514
    TargetHumans

    Activates transcription of transcription factor FOXR1 which in turn activates transcription of the heat shock chaperones HSPA1A and HSPA6 and the antioxidant NADPH-dependent reductase DHRS2 (PubMed:34723967 … Functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class

    Polypeptides: Heat shock factor protein 1Synonyms: Heat shock transcription factor 1
  3. Target

    Hepatocyte nuclear factor 4-alpha

    go.drugbank.com/bio_entities/BE0004019
    TargetHumans

    Represses the CLOCK-BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (PubMed:30530698)

    Polypeptides: Hepatocyte nuclear factor 4-alphaSynonyms: Transcription factor 14, Transcription factor HNF-4
  4. Target

    Elongation factor-like GTPase 1

    go.drugbank.com/bio_entities/BE0004053
    TargetHumans

    EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export … GTPase involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes.

    Polypeptides: Elongation factor-like GTPase 1Synonyms: Elongation factor-like 1, Elongation factor Tu GTP-binding domain-containing protein 1
  5. Target

    Myocardin-related transcription factor A

    go.drugbank.com/bio_entities/BE0004156
    TargetHumans

    Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell

    Polypeptides: Myocardin-related transcription factor A
  6. Target

    Stromal cell-derived factor 2

    go.drugbank.com/bio_entities/BE0004444
    TargetHumans

    Polypeptides: Stromal cell-derived factor 2
  7. Target

    Vascular endothelial growth factor B

    go.drugbank.com/bio_entities/BE0004736
    TargetHumans

    Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis

    Polypeptides: Vascular endothelial growth factor BSynonyms: VEGF-related factor
  8. Target

    Nuclear factor NF-kappa-B

    go.drugbank.com/bio_entities/BE0004903
    TargetHumans

    NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to … NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to

    Polypeptides: Nuclear factor NF-kappa-B p100 subunit, Nuclear factor NF-kappa-B p105 subunitSynonyms: DNA-binding factor KBF2, DNA-binding factor KBF1
  9. Target

    Splicing factor 3A subunit 2

    go.drugbank.com/bio_entities/BE0008966
    TargetHumans

    Interacts directly with the duplex formed by U2 snRNA and the intron (PubMed:29360106) … Within the 17S U2 SnRNP complex, SF3A2 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic

    Polypeptides: Splicing factor 3A subunit 2
  10. Target

    Eukaryotic translation initiation factor 6

    go.drugbank.com/bio_entities/BE0008972
    TargetHumans

    Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. … In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or

    Polypeptides: Eukaryotic translation initiation factor 6