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Displaying results 181 - 190 of 204 in total
  1. Target

    Glutamate (NMDA) receptor

    go.drugbank.com/bio_entities/BE0004852
    TargetHumans

    Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed: … Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:

    Synonyms: N-methyl-D-aspartate receptor subunit NR1, N-methyl D-aspartate receptor subtype 2A
  2. Target

    NMDA receptor

    go.drugbank.com/bio_entities/BE0004956
    TargetHumans

    Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed: … Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:

    Synonyms: N-methyl-D-aspartate receptor subunit NR1, N-methyl D-aspartate receptor subtype 2A
  3. Target

    Purine nucleoside phosphorylase

    go.drugbank.com/bio_entities/BE0003172
    TargetPlasmodium falciparum (isolate 3D7)

    Preferentially acts on inosine and guanosine, and to a lesser extent on 2'-deoxyguanosine and guanosine (PubMed:14982926, PubMed:16131758, PubMed:19575810). … Also catalyzes the phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine; MTI is produced by adenosine deaminase (ADA)-mediated breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product

    Synonyms: S-methyl-5'-thioinosine phosphorylase
  4. Target

    Pyruvate Kinases

    go.drugbank.com/bio_entities/BE0009686
    EnzymeTargetHumans

    The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival (PubMed:15996096, PubMed:1854723, PubMed:20847263) … Pyruvate kinase that catalyzes the conversion of phosphoenolpyruvate to pyruvate with the synthesis of ATP, and which plays a key role in glycolysis (PubMed:11960989).

    Synonyms: OIP-3
  5. Target

    Branched-chain alpha-ketoacid dehydrogenase kinase

    go.drugbank.com/bio_entities/BE0004571
    TargetHumans

    and oxaloacetate immediate substrates of de novo lipogenesis and glucogenesis, respectively (PubMed:29779826). … Associates with the E2 component of BCKDH complex and phosphorylates BCKDHA on Ser-337, leading to conformational changes that interrupt substrate channeling between E1 and E2 and inactivates the BCKDH

    Synonyms: [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrialFunction: [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity
  6. Target

    Methylsterol monooxygenase 1

    go.drugbank.com/bio_entities/BE0000096
    TargetHumans

    Catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, which can be subsequently metabolized to cholesterol (PubMed:21285510, PubMed:23583456, … 71 or 1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)-cholecalciferol), a second-generation vitamin D analog, into 1alpha,2beta,25-trihydroxy vitamin D3; this reaction occurs via enzymatic hydroxylation and

    Synonyms: Sterol-C4-methyl oxidase
  7. Target

    Glutamate receptor ionotropic, NMDA 3A

    go.drugbank.com/bio_entities/BE0000641
    TargetHumans

    Component of a non-conventional N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with low calcium permeability and low voltage-dependent block … Forms glutamatergic receptor complexes with GluN1 and GluN2 subunits which are activated by glycine binding to the GluN1 and GluN3 subunits and L-glutamate binding to GluN2 subunits (By similarity).

    Synonyms: N-methyl-D-aspartate receptor subtype 3A
  8. Target

    Hydroxyethylthiazole kinase

    go.drugbank.com/bio_entities/BE0001879
    TargetBacillus subtilis (strain 168)

    Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

    Synonyms: 4-methyl-5-beta-hydroxyethylthiazole kinase
  9. Target

    Glutamate receptor ionotropic, NMDA 2C

    go.drugbank.com/bio_entities/BE0000454
    TargetHumans

    Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed: … NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium (By similarity).

    Synonyms: N-methyl D-aspartate receptor subtype 2C
  10. Target

    Glutamate receptor ionotropic, NMDA 2A

    go.drugbank.com/bio_entities/BE0000760
    TargetHumans

    Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed: … NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium (By similarity).

    Synonyms: N-methyl D-aspartate receptor subtype 2A