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Ropivacaine Action Pathway
smpdb.ca/view/SMP0000404Drug actionRopivacaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Ropivacaine diffuses across the neuronal plasma membrane in its uncharged base form. Once inside the cytoplasm, it is proton...
Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1Heroin Action Pathway
smpdb.ca/view/SMP0000407Drug actionHeroin is a mu-opioid agonist. It acts on endogenous mu-opioid receptors that are spread in discrete packets throughout the brain, spinal cord and gut in almost all mammals. Heroin, along with other opioids, are agonists to four endogeno...
Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1Levallorphan Action Pathway
smpdb.ca/view/SMP0000683Drug actionLevallorphan (also known as Lorfan and Naloxifan) is a type of medication that can be used for treating drug overdoses and respirotry depression. Levallorphan can bind to mu-type opioid receptor and kappa-type opioid receptor on neuron o...
Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1Buprenorphine Action Pathway
smpdb.ca/view/SMP0000684Drug actionBuprenorphine, trade name subutex, suboxone, zubsolv and bunavail, is a partial agonist of mu-opioid receptors and a kappa-opioid receptor antagonist and is prescribed for opioid addiction to prevent cravings and symptoms of withdrawal. ...
Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1Naltrexone Action Pathway
smpdb.ca/view/SMP0000687Drug actionNaltrexone (also known as ReVia and Vivitrol) is a competitive antagonist of mu-type opioid receptor in the central nervous system (CNS). Naltrexone is also a type of medication that are used for manage opioid or alcohol dependence. Bind...
Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1Nalbuphine Action Pathway
smpdb.ca/view/SMP0000691Drug actionNalbuphine (also known as Rubuphine and Nubain) is a competitive antagonist of mu-type and kappa-type opioid receptor in the central nervous system (CNS). Nalbuphine is also a type of medication that are mainly used for treat pain. Bindi...
Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1Nicotine Action Pathway
smpdb.ca/view/SMP0000431Drug actionThis causes the channel to open and allow conductance of multiple cations including sodium, calcium, and potassium.
Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1Verapamil Calcium Channel Cardiac Muscle Relaxation Action Pathway
smpdb.ca/view/SMP0126428Drug actionVerapamil, known as the brand names Calan, Isoptin, Tarka, and Verelan, is a non-dihydropyridine calcium channel blocker used in the treatment of angina, arrhythmia, and hypertension. It is used for the treament of vasopastic angina, uns...
Enzymes: Potassium channel subfamily K member 1, Inward rectifier potassium channel 4Diltiazem Calcium Channel Cardiac Muscle Relaxation Action Pathway
smpdb.ca/view/SMP0126292Drug actionDiltiazem is a calcium channel blocker used to treat hypertension and to manage chronic stable angina. It can be found under the names Cardizem, Cartia, Matzim, Taztia, Tiadylt, and Tiazac. Diltiazem is a benzothiazepine derivative with ...
Enzymes: Potassium channel subfamily K member 1, Inward rectifier potassium channel 4Cocaine Action Pathway
smpdb.ca/view/SMP0000395Drug actionCocaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Cocaine diffuses across the neuronal plasma membrane in its uncharged base form. Once inside the cytoplasm, it is protonated and...
Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1