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T-cell surface glycoprotein CD3 delta chain
go.drugbank.com/bio_entities/BE0003456TargetHumansWhen antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD247/CD3Z.
Synonyms: T-cell receptor T3 delta chainT-cell surface glycoprotein CD3 gamma chain
go.drugbank.com/bio_entities/BE0003457TargetHumansIndeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G … When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD247/CD3Z.
Synonyms: T-cell receptor T3 gamma chainP2Y purinoceptor 4
go.drugbank.com/bio_entities/BE0009822TargetHumansReceptor for UTP and UDP coupled to G proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP
Synonyms: Uridine nucleotide receptorFunction: G protein-coupled purinergic nucleotide receptor activitySolute carrier family 52, riboflavin transporter, member 2
go.drugbank.com/bio_entities/BE0004841TargetTransporterHumansMay also act as a receptor for 4-hydroxybutyrate (Probable)
Synonyms: PERV-A receptor 1, Porcine endogenous retrovirus A receptor 1Function: 4-hydroxybutyrate receptor activityP2Y purinoceptor 12
go.drugbank.com/bio_entities/BE0000110TargetHumansReceptor for ADP and ATP coupled to G proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Required for normal platelet aggregation and blood coagulation
Synonyms: ADP-glucose receptor, P2Y12 platelet ADP receptorFunction: G protein-coupled adenosine receptor activityGrowth arrest-specific protein 6
go.drugbank.com/bio_entities/BE0010201TargetHumansLigand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration.
Synonyms: AXL receptor tyrosine kinase ligandDidesmethylrocaglamide
go.drugbank.com/drugs/DB15496ExperimentalDidesmethylrocaglamide is a naturally-occurring derivative of rocaglamide and belongs to a class of anti-cancer phytochemicals referred to as "rocaglamides" derived from plants of the genus Aglaia. While traditionally used for their inse...
T-cell surface glycoprotein CD3
go.drugbank.com/bio_entities/BE0010202TargetHumansIn addition to its role as a TCR coreceptor, it serves as a receptor for ITPRIPL1 (PubMed:38614099). … Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G
Synonyms: T-cell receptor T3 delta chain, T-cell receptor T3 zeta chainRocaglamide
go.drugbank.com/drugs/DB15495ExperimentalRocaglamide, also referred to as rocaglamide-A, is the eponymous member of a class of anti-cancer phytochemicals known as rocaglamides. Rocaglamides are secondary metabolites of the plant genus Aglaia, and extracts of the plant have trad...
Dual specificity mitogen-activated protein kinase kinase 4
go.drugbank.com/bio_entities/BE0010122TargetHumansDual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2...
Synonyms: MEK 4