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Displaying results 11 - 20 of 125 in total
  1. Target

    Succinyl-CoA Synthetases

    go.drugbank.com/bio_entities/BE0009689
    EnzymeHumans

    Also able to act as an itaconyl- and malyl-CoA synthetase (PubMed:40108300) … ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation

    Polypeptides: Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial, Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrialSynonyms: Succinyl-CoA synthetase beta-A chain, Succinyl-CoA synthetase subunit alpha
  2. Target

    2,4-dienoyl-CoA reductase [(2E)-enoyl-CoA-producing]

    go.drugbank.com/bio_entities/BE0001961
    TargetEscherichia coli (strain K12)

    Catalyzes the NADPH-dependent reduction of the C4-C5 double bond of the acyl chain of 2,4-dienoyl-CoA to yield 2-trans-enoyl-CoA (PubMed:6363415, PubMed:9346310). … Acts on both isomers, 2-trans,4-cis- and 2-trans,4-trans-decadienoyl-CoA, with almost equal efficiency (PubMed:6363415). Is not active with NADH instead of NADPH (PubMed:6363415).

    Polypeptides: 2,4-dienoyl-CoA reductase [(2E)-enoyl-CoA-producing]Synonyms: 2,4-dienoyl-CoA reductase [NADPH]
  3. Target

    4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase

    go.drugbank.com/bio_entities/BE0002977
    TargetClostridium aminobutyricum

    Catalyzes the reversible conversion of 4-hydroxybutyryl-CoA to crotonyl-CoA. … from the now reduced FAD in an SN2' reaction leading to vinylacetyl-CoA; (3) isomerization to yield crotonyl-CoA.

    Polypeptides: 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase
  4. Target

    2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial

    go.drugbank.com/bio_entities/BE0003119
    TargetHumans

    Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA (PubMed:15531764). … Together with the Enoyl-CoA delta isomerase 1 (ECI1) and the Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase (ECH1) they allow reentrance of the enoyl-CoA into the beta-oxidation cycle (PubMed:26474213).

    Polypeptides: 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrialSynonyms: 4-enoyl-CoA reductase [NADPH], 2,4-dienoyl-CoA reductase [NADPH]
  5. Target

    Acetyl-CoA acetyltransferase, mitochondrial

    go.drugbank.com/bio_entities/BE0000069
    TargetHumans

    Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (PubMed:1715688, PubMed:7728148, PubMed … The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA (PubMed:17371050).

    Polypeptides: Acetyl-CoA acetyltransferase, mitochondrialSynonyms: Acetoacetyl-CoA thiolase
  6. Target

    Acyl-CoA 6-desaturase

    go.drugbank.com/bio_entities/BE0002246
    TargetEnzymeHumans

    In addition to Delta-6 activity, this enzyme exhibits Delta-8 activity with slight biases toward n-3 fatty acyl-CoA substrates (By similarity) … unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors, acting as a fatty acyl-coenzyme A (CoA

    Polypeptides: Acyl-CoA 6-desaturaseFunction: acyl-CoA 6-desaturase activity
  7. Target

    4-chlorobenzoyl CoA dehalogenase

    go.drugbank.com/bio_entities/BE0002495
    TargetPseudomonas sp. DJ-12

    Polypeptides: 4-chlorobenzoyl CoA dehalogenase
  8. Target

    2-aminobenzoylacetyl-CoA thioesterase

    go.drugbank.com/bio_entities/BE0003865
    TargetPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)

    In vitro, can also hydrolyze other substrates such as S-ethyl-acetothioacetate and acetoacetyl-CoA, but is inactive against anthraniloyl-CoA, malonyl-CoA and octanoyl-CoA (PubMed:25960261, PubMed:27082157 … Catalyzes the hydrolysis of the intermediate 2-aminobenzoylacetyl-CoA (2-ABA-CoA) to form 2-aminobenzoylacetate (2-ABA), the precursor of HHQ.

    Polypeptides: 2-aminobenzoylacetyl-CoA thioesterase
  9. Target

    glutaryl-CoA dehydrogenase (ETF)

    go.drugbank.com/bio_entities/BE0004375
    TargetBurkholderia pseudomallei (strain 1710b)

    Polypeptides: glutaryl-CoA dehydrogenase (ETF)Synonyms: Glutaryl-CoA dehydrogenase
  10. Target

    Enoyl-CoA hydratase, mitochondrial

    go.drugbank.com/bio_entities/BE0004500
    TargetHumans

    Has high substrate specificity for crotonyl-CoA ((2E)-butenoyl-CoA) and moderate specificity for acryloyl-CoA, 3-methylcrotonyl-CoA (3-methyl-(2E)-butenoyl-CoA) and methacrylyl-CoA ((2E)-2-methylpropenoyl-CoA … At a lower rate than the hydratase reaction, catalyzes the isomerase reaction of trans-3-enoyl-CoA species (such as (3E)-hexenoyl-CoA) to trans-2-enoyl-CoA species (such as (2E)-hexenoyl-CoA), which are

    Polypeptides: Enoyl-CoA hydratase, mitochondrialSynonyms: Enoyl-CoA hydratase 1, Short-chain enoyl-CoA hydratase