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Displaying results 11 - 20 of 53 in total
  1. Target

    Botulinum neurotoxin type C

    go.drugbank.com/bio_entities/BE0009353
    TargetClostridium botulinum

    Botulinum neurotoxin type C Botulinum toxin causes flaccid paralysis by inhibiting neurotransmitter (acetylcholine) release from the presynaptic membranes of nerve terminals of the eukaryotic host … Upon synaptic vesicle recycling the toxin is taken up via the endocytic pathway.

    Polypeptides: Botulinum neurotoxin type CSynonyms: Botulinum neurotoxin type C1
  2. Target

    Botulinum neurotoxin type E

    go.drugbank.com/bio_entities/BE0009355
    TargetClostridium botulinum

    Botulinum neurotoxin type E Botulinum toxin causes flaccid paralysis by inhibiting neurotransmitter (acetylcholine) release from the presynaptic membranes of nerve terminals of eukaryotic host skeletal … Upon synaptic vesicle recycling the toxin is taken up via the endocytic pathway.

    Polypeptides: Botulinum neurotoxin type E
  3. Target

    Botulinum neurotoxin type F

    go.drugbank.com/bio_entities/BE0009356
    TargetClostridium botulinum

    Botulinum neurotoxin type F Botulinum toxin causes flaccid paralysis by inhibiting neurotransmitter (acetylcholine) release from the presynaptic membranes of nerve terminals of the eukaryotic host … Upon synaptic vesicle recycling the toxin is taken up via the endocytic pathway.

    Polypeptides: Botulinum neurotoxin type F
  4. Target

    Botulinum neurotoxin type G

    go.drugbank.com/bio_entities/BE0009357
    TargetClostridium botulinum

    Botulinum neurotoxin type G Botulinum toxin causes flaccid paralysis by inhibiting neurotransmitter (acetylcholine) release from the presynaptic membranes of nerve terminals of the eukaryotic host … uptake of toxin into host cells (PubMed:15123599).

    Polypeptides: Botulinum neurotoxin type G
  5. Target

    Botulinum neurotoxin type D

    go.drugbank.com/bio_entities/BE0009354
    TargetClostridium botulinum

    Botulinum neurotoxin type D Botulinum toxin causes flaccid paralysis by inhibiting neurotransmitter (acetylcholine) release from the presynaptic membranes of nerve terminals of the eukaryotic host … Precursor of botulinum neurotoxin D for which a proteinaceous coreceptor is controversial.

    Polypeptides: Botulinum neurotoxin type D
  6. Target

    Botulinum neurotoxin type B

    go.drugbank.com/bio_entities/BE0001263
    TargetEnzymeClostridium botulinum

    Botulinum neurotoxin type B Botulinum toxin causes flaccid paralysis by inhibiting neurotransmitter (acetylcholine) release from the presynaptic membranes of nerve terminals of the eukaryotic host … Toxin uptake into neural cells requires stimulation (incubation with K(+) to stimulate SYT protein receptor exposure); subsequently the toxin colocalizes with its receptor in host cells with a concomitant

    Polypeptides: Botulinum neurotoxin type B
  7. Target

    Bontoxilysin-A

    go.drugbank.com/bio_entities/BE0004102
    TargetClostridium botulinum

    Polypeptides: Bontoxilysin-ASynonyms: Botulinum neurotoxin type A, Neurotoxin type A
  8. Drug

    DaxibotulinumtoxinA

    go.drugbank.com/drugs/DB17929
    ApprovedInvestigational

    It is a botulinum toxin without accessory proteins purified from the bacterium _Clostridium botulinum_ type A,[L47840] the gram-positive anaerobic bacterium primarily present in soil. … _C. botulinum_ is known to produce toxins that can cause botulism in humans.

    Categories: Botulinum Toxins, Type A, Botulinum Toxins
  9. Target

    NADPH oxidase

    go.drugbank.com/bio_entities/BE0004904
    TargetHumans

    Subunit of NADPH oxidase complexes that is required for the NADPH oxidase activity that generates, in various cell types, superoxide from molecular oxygen utilizing NADPH as an electron donor (PubMed:15824103 … In neurons, plays a crucial role in regulating GABA(A) receptor synaptic stability and hence GABAergic inhibitory synaptic transmission through its role in PAK1 activation and eventually F-actin stabilization

    Polypeptides: Ras-related C3 botulinum toxin substrate 1, Ras-related C3 botulinum toxin substrate 2
  10. Indication

    Chronic Migraine

    go.drugbank.com/conditions/DBCOND0042084
    Drugs: Botulinum toxin type A
    Synonyms: Migraine type headaches