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Displaying results 11 - 20 of 186 in total
  1. Target

    NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

    go.drugbank.com/bio_entities/BE0000729
    TargetEnzymeHumans

    Essential for glia-like neural stem and progenitor cell proliferation, differentiation and subsequent oligodendrocyte or neuronal maturation (By similarity) … Plays an important role in carotid body sensing of hypoxia (By similarity).

    Polypeptides: NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
  2. Target

    NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial

    go.drugbank.com/bio_entities/BE0000037
    TargetHumans

    Essential for the catalytic activity and assembly of complex I (PubMed:22499348) … Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor

    Polypeptides: NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrialFunction: 4 iron, 4 sulfur cluster binding
  3. Target

    NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

    go.drugbank.com/bio_entities/BE0000093
    TargetHumans

    Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The ...

    Polypeptides: NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
  4. Target

    NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

    go.drugbank.com/bio_entities/BE0000307
    TargetEnzymeHumans

    Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor

    Polypeptides: NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrialFunction: 4 iron, 4 sulfur cluster binding
  5. Target

    Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide

    go.drugbank.com/bio_entities/BE0001300
    TargetHumans

    May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K

    Polypeptides: Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide
  6. Target

    Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)

    go.drugbank.com/bio_entities/BE0000423
    TargetTransporterHumans

    Transports non-alpha-amino acids such as beta-alanine with low affinity, and has a higher affinity for dipolar and cationic amino acids such as leucine and lysine (PubMed:18599538). … Can also transport carnitine, butirylcarnitine and propionylcarnitine coupled to the transmembrane gradients of Na(+) and Cl(-) (PubMed:17855766)

    Polypeptides: Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)
  7. Target

    B- and T-lymphocyte attenuator

    go.drugbank.com/bio_entities/BE0010629
    TargetHumans

    Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:12796776, PubMed:14652006, PubMed:15568026, PubMed:18193050). … In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state.

    Polypeptides: B- and T-lymphocyte attenuatorSynonyms: B- and T-lymphocyte-associated protein
  8. Target

    Splicing factor, proline- and glutamine-rich

    go.drugbank.com/bio_entities/BE0008965
    TargetHumans

    During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release … The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity.

    Polypeptides: Splicing factor, proline- and glutamine-rich
  9. Target

    Cocaine- and amphetamine-regulated transcript protein

    go.drugbank.com/bio_entities/BE0000867
    TargetHumans

    Satiety factor closely associated with the actions of leptin and neuropeptide Y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced … It promotes neuronal development and survival in vitro

    Polypeptides: Cocaine- and amphetamine-regulated transcript protein
  10. Target

    Multidrug and toxin extrusion protein 1

    go.drugbank.com/bio_entities/BE0003657
    TransporterTargetHumans

    Plays a physiological role in the excretion of cationic compounds including endogenous metabolites, drugs, toxins through the kidney and liver, into urine and bile respectively (PubMed:16330770, PubMed … Mediates the efflux of endogenous compounds such as creatinine, vitamin B1/thiamine, agmatine and estrone-3-sulfate (PubMed:16330770, PubMed:17495125, PubMed:17509534, PubMed:17582384, PubMed:18305230,

    Polypeptides: Multidrug and toxin extrusion protein 1