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Echothiophate Action Pathway
smpdb.ca/view/SMP0126704Drug actionDoing so causes miosis (constriction of the pupil) causing an outflow of aqueous humor and reducing intraocular pressure. … Side effects such as change in vision both near or far, eye pain and blurred vision can occur.
Phenserine Action Pathway
smpdb.ca/view/SMP0126724Drug actionIt acts as a highly selective reversible acetylcholinesterase inhibitor, which is known to increase acetylcholine levels in the synaptic cleft and enhance the interaction between the neurotransmitter and … This mechanism of action is known to improve memory and cognition in alzheimer's subjects.
Physostigmine Action Pathway
smpdb.ca/view/SMP0125085Drug actionIn the neuron, acetylcholine is synthesized form acetyl-coa and choline, and stored into synaptic vesicles. … This increase results in increased aqueous humor flow and a decrease in intraocular pressure.
Atropine M1/3/5 Muscarinic Poisoning Action Pathway
smpdb.ca/view/SMP0125413Drug actionSince myosine light chain kinase is not activated, Serine/threonine-protein phosphatase continues to dephosphorylate myosin LC-P, and more cannot be synthesized so myosin remains unbound from actin causing … Atropine is a muscarinic agents used to treat poisoning by muscarinic agents such as organophosphates and other muscarinic drugs.
Procyclidine M1 Antispasmodic Action Pathway
smpdb.ca/view/SMP0126398Drug actionA muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorders and in parkinsonism. … Procyclidine exerts an antispasmodic effect on smooth muscle, and may produce mydriasis and reduction in salivation. By blocking the M1 receptor, the action of acetylcholine is blocked.
Donepezil Action Pathway
smpdb.ca/view/SMP0126613Drug actionDonepezil is an acetylcholinesterase inhibitor also known as Adlarity, Aricept and Namzaric, that is used in the treatment of Alzheimer's Disease and dementia. … Donepezil goes through first-pass metabolism by CYP3A4 and CYP2D6 into metabolites which can be further broken down by dealkylation, hydroxylation, oxidation, hydrolysis and glucuronidation.
Galantamine Action Pathway (new, revision)
smpdb.ca/view/SMP0126671Drug actionThe drug is metabolized by enzymes CYP2D6 and CYP3A4 into metabolites. … It also acts as an allosteric modulator for the neuronal acetylcholine receptor, helping control the release of neurotransmitters like acetylcholine, GABA, glutamate, dopamine, serotonin and norepinephrine
Minaprine Acetylcholinesterase Antidepressant Action Pathway
smpdb.ca/view/SMP0126689Drug actionFirstly, this drug binds as an antagonist to the serotonin type 2 receptors (C, B, and C). Secondly, it can also antagonize the dopamine D1 and D2 type receptors. … The first one is found in cells located in the periphery and breakdown serotonin, norepinephrine, epinephrine, dopamine, and tyramine.
Metrifonate Action Pathway
smpdb.ca/view/SMP0126725Drug actionand alzheimer's disease. … While binding to acetylcholinesterase it prevents the breakdown of acetylcholine, allowing the neurotransmitter to interact with the receptors that help aid memory and cognition in patients with dementia
Dutasteride Action Pathway
smpdb.ca/view/SMP0126518Drug actionThis effect is dose-dependent and reduces the size of the prostate gland, improving the urinary flow and the symptoms of benign prostatic hyperplasia alone. … Dutasteride is a synthetic 4-azasteroid that is used as an antiandrogenic drug. It is used to treat symptomatic benign and symptomatic prostatic hyperplasia (BPH) in adult males.