Metrifonate

DB11473ExperimentalVet approvedSmall molecule

Metrifonate or trichlorfon is an irreversible organophosphate acetylcholinesterase inhibitor. It is a prodrug which is activated non-enzymatically into 2,2-dichlorovinyl dimethyl phosphate.

Chemical structure of Metrifonate
Mechanism
Curator reviewed
Formula / weight
C4H8Cl3O4P · 257.437 g/mol (avg)
Also known as
Chlorophos · Methyl chlorophos · Trichlorfon

Resolves to

Compound
UNIIDBF2DG4G2KCAS52-68-6ChEMBLCHEMBL167150ChEBI6908KEGGD00805
Clinical / RWD
RxNorm1000581ATCP02BB01
Structure
InChIKeyNFACJZMKEDPNKN-UHFFFAOYSA-NSMILESCOP(=O)(OC)C(O)C(Cl)(Cl)Cl
Targets
P22303ACHEP06276BCHE

What you can answer from here — as of July 07, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action
Listed above
292Drug interactionsStructured to mechanism, not free text
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1ATC codeIncluding every combination product, plus 17 drug categories
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18+ReferencesStructured and connected to the statements they support
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Which drugs share a target with Metrifonate, and which of those have an active Phase 3 trial?

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