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Displaying results 191 - 200 of 134683 in total
  1. Pathway

    Lactose Intolerance

    smpdb.ca/view/SMP0000458
    Disease

    Lactase deficiency is most prevalent in Asia, Africa and Indigenous populations in North and South America. … The symptoms of lactose intolerance include diarrhea, bloating, abdominal pain and excessive flatus.

    Drugs: ATP · Potassium cation · Lactose
    Enzymes: Sodium/glucose cotransporter 1, Sodium/potassium-transporting ATPase subunit alpha-1
  2. Pathway

    Trehalose Degradation

    smpdb.ca/view/SMP0000467
    Metabolic

    These are then transported into the epithelial cells along with a sodium ion by a sodium/glucose cotransporter, which can bring glucose up its gradient along with sodium moving down its gradient. … It is produced by some plants, bacteria, fungi and invertebrates, and can be used as a source of energy, such as for flight in insects, and as a survival mechanism to avoid freezing and dehydration.

    Drugs: ATP · Potassium cation
    Enzymes: Sodium/glucose cotransporter 1, Sodium/potassium-transporting ATPase subunit alpha-1
  3. Pathway

    Lactose Intolerance

    smpdb.ca/view/SMP0125808
    Disease

    Lactase deficiency is most prevalent in Asia, Africa and Indigenous populations in North and South America. … The symptoms of lactose intolerance include diarrhea, bloating, abdominal pain and excessive flatus.

    Drugs: ATP · Potassium cation · Lactose
    Enzymes: Sodium/glucose cotransporter 1, Sodium/potassium-transporting ATPase subunit alpha-1
  4. Pathway

    Kidney Function - Collecting Duct

    smpdb.ca/view/SMP0121011
    Physiological

    In addition, sodium and potassium are also reabsorbed back into the systemic circulation at the collecting duct via potassium and sodium channels. … As a result, a high concentration of sodium and potassium in the blood vessels occurs. Some urea and other ions may be reabsorbed as well.

    Drugs: Potassium cation · Zinc · Urea
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  5. Pathway

    Phenytoin (Antiarrhythmic) Action Pathway

    smpdb.ca/view/SMP0000327
    Drug action

    Sodium channels then close and rapidly activated potassium channels such as the voltage-gated transient outward delayed rectifying potassium channel (I-Kto) and the voltage-gated ultra rapid delayed rectifying … Membrane ion pumps, such as the sodium-potassium ATPase and sodium-calcium exchanger (NCX), maintain low intracellular sodium (5 mM) and calcium (100 nM) concentrations and high intracellular potassium

    Drugs: Ademetionine · ATP · Phenytoin · Potassium cation · Calcium · Magnesium cation +3 more
    Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, G protein-activated inward rectifier potassium channel 4
  6. Pathway

    Torasemide Action Pathway (New)

    smpdb.ca/view/SMP0124537
    Drug action

    Torasemide binds to NKCC2 transporter and inhibits it, preventing Na+, K+ and Cl- reabsorption from the lumen. … The K+/Cl- co-transporter moves K+ and Cl- from the cell into the peritubular fluid and the Cl- channel transports Cl- from the cell into the peritubular fluid.

    Drugs: Torasemide · Potassium cation
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  7. Pathway

    Ethacrynic Acid Diuretic Action Pathway

    smpdb.ca/view/SMP0124515
    Drug action

    This is relieves symptoms such as swelling/ edema and hypertension in patients. Ethacrynic acid may also inhibit sodium and chloride reabsorption in the proximal and distal tubules. … Ethacrynic acid binds to NKCC2 transporter and inhibits it, preventing Na+, K+ and Cl- reabsorption from the lumen.

    Drugs: Etacrynic acid · Potassium cation
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  8. Pathway

    17-beta Hydroxysteroid Dehydrogenase III Deficiency

    smpdb.ca/view/SMP0000356
    Disease

    disorder of the androgen and estrogen metabolism pathway. … This leads to an accumulation of androstenedione and dehydroepiandrosterone in the body, as well as a lack of testosterone produced. 17-KSR deficiency is characterized by an absence of testosterone in

    Drugs: NADH · Testosterone · Estrone · Estradiol · Calcium · Androstenedione +6 more
    Enzymes: Steryl-sulfatase
  9. Pathway

    Aromatase Deficiency

    smpdb.ca/view/SMP0125782
    Disease

    Symptoms of decrease in estrogen and increase androgens such as testosterone can cause impaired female sexual development, unusual bone growth, insulin resistance, and a variety of other symptoms. … Aromatase converts androgens to estrogens which is vital for bone growth and regulation of blood sugar levels.

    Drugs: NADH · Testosterone · Estrone · Estradiol · Calcium · Androstenedione +6 more
    Enzymes: Steryl-sulfatase
  10. Pathway

    Pantoprazole Action Pathway

    smpdb.ca/view/SMP0123293
    Drug action

    In parietal cells, carbonic anhydrase converts water and carbon dioxide to hydrogen bicarbonate ions and H+. … The H+/K+ ATPase is located on the apical membrane and pumps the H+ from the cell into the stomach lumen and K+ from the lumen into the cell.

    Drugs: Pantoprazole · Potassium cation · Zinc
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1