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Displaying results 191 - 200 of 208 in total
  1. Target

    Hypoxia-inducible factor 1-alpha

    go.drugbank.com/bio_entities/BE0002374
    TargetHumans

    Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose … Interaction with redox regulatory protein APEX1 seems to activate CTAD and potentiates activation by NCOA1 and CREBBP (PubMed:10202154, PubMed:10594042).

    Synonyms: Basic-helix-loop-helix-PAS protein MOP1, Class E basic helix-loop-helix protein 78
  2. Target

    Hypoxia-inducible factor 1

    go.drugbank.com/bio_entities/BE0010297
    TargetHumans

    Transcription factor that functions as an obligate heterodimerization partner for several basic helix-loop-helix PER-ARNT-SIM (bHLH-PAS) proteins. … Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose

    Synonyms: Class E basic helix-loop-helix protein 2, Basic-helix-loop-helix-PAS protein MOP1
  3. Target

    Nuclear receptor coactivator 2

    go.drugbank.com/bio_entities/BE0003740
    TargetHumans

    Required with NCOA1 to control energy balance between white and brown adipose tissues (PubMed:23508108, PubMed:8670870, PubMed:9430642). … Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:23508108, PubMed:8670870, PubMed:9430642, PubMed:22504882, PubMed:26553876).

    Synonyms: Class E basic helix-loop-helix protein 75
  4. Target

    G protein-coupled estrogen receptor 1

    go.drugbank.com/bio_entities/BE0003446
    TargetHumans

    Regulates arterial blood pressure by stimulating vasodilation and reducing vascular smooth muscle and microvascular endothelial cell proliferation. … Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor

    Synonyms: CEPR
  5. Target

    Sterol regulatory element-binding protein 1

    go.drugbank.com/bio_entities/BE0005540
    TargetHumans

    and lipid homeostasis (By similarity) … Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis

    Synonyms: Class D basic helix-loop-helix protein 1
  6. Target

    Porin D

    go.drugbank.com/bio_entities/BE0003974
    TargetPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)

    Porin with a specificity for basic amino acids. Also possesses serine protease activity.

    Synonyms: Imipenem/basic amino acid-specific outer membrane pore
  7. Target

    Bile acid receptor

    go.drugbank.com/bio_entities/BE0001777
    TargetHumans

    Also regulates lipid and glucose homeostasis and is involved innate immune response (PubMed:10334992, PubMed:10334993, PubMed:21383957, PubMed:22820415). … SDC1 (involved in the hepatic uptake of LDL and IDL remnants), and inhibiting expression of MTTP (involved in VLDL assembly (PubMed:12554753, PubMed:12660231, PubMed:15337761).

    Synonyms: BAR
  8. Target

    Endothelial PAS domain-containing protein 1

    go.drugbank.com/bio_entities/BE0009679
    TargetHumans

    Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. … Activation requires recruitment of transcriptional coactivators such as CREBBP and probably EP300. Interaction with redox regulatory protein APEX1 seems to activate CTAD (By similarity)

    Synonyms: Basic-helix-loop-helix-PAS protein MOP2, Class E basic helix-loop-helix protein 73
  9. Target

    Aryl hydrocarbon receptor nuclear translocator

    go.drugbank.com/bio_entities/BE0010296
    TargetHumans

    Transcription factor that functions as an obligate heterodimerization partner for several basic helix-loop-helix PER-ARNT-SIM (bHLH-PAS) proteins. … Plays a central role in environmental sensing and developmental and physiological regulation of gene expression (PubMed:34521881)

    Synonyms: Class E basic helix-loop-helix protein 2
  10. Target

    Adenylosuccinate synthetase isozyme 1

    go.drugbank.com/bio_entities/BE0002231
    TargetHumans

    Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis.

    Synonyms: Adenylosuccinate synthetase, basic isozyme