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Sufentanil Action Pathway
smpdb.ca/view/SMP0000417Drug actionand decrease in cAMP production. … It also inhibits nociceptive neurotransmitter release and induces membrane hyperpolarization. Analgesia, anesthesia, and respiratory depression are a consequence of remifentanial’s action.
Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium channel protein type 10 subunit alphaDesipramine Action Pathway
smpdb.ca/view/SMP0000423Drug actionIt does so by competing for the same binding site as norepinephrine on the sodium-dependent noradraneline transporter (SLC6A2) and by competing with serotonin for binding to the sodium-dependent serotonin … This increases the concentrations of both norepinephrine and serotonin in their respective synapses and reverses the state of low concentrations of both neurotransmitters found in depression.
Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium channel protein type 10 subunit alphaEscitalopram Action Pathway
smpdb.ca/view/SMP0000425Drug actionCREB-1 enters the nucleus and affects transcription of brain-derived neurotrophic factor (BDNF). … It does so by competing for the same binding site as serotonin on the the sodium-dependent serotonin transporter (SLC6A4).
Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium channel protein type 10 subunit alphaPropoxyphene Action Pathway
smpdb.ca/view/SMP0000672Drug actionOpioids inhibit vasopressin, somatostatin, insulin and glucagon release. … Propoxyphene also causes the closure of voltage-gated calcium channels and opens potassium channels causing the hyperpolarization of the membrane and decreasing neuronal excitability.
Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium channel protein type 10 subunit alphaLevorphanol Action Pathway
smpdb.ca/view/SMP0000673Drug actionThe binding of levorphanol will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter. … Therefore, levorphanol can reduce nerve conduction and decrease neurotransmitter release; so that perception of pain signals can be blocked.
Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium channel protein type 10 subunit alphaAnileridine Action Pathway
smpdb.ca/view/SMP0000674Drug actionThe binding of anileridine will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter. … Hyperpolarization of neuron is caused by inactivation of calcium channels and activation of potassium channels via facilitated by G-protein.
Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium channel protein type 10 subunit alphaEthylmorphine Action Pathway
smpdb.ca/view/SMP0000681Drug actionEthylmorphine (also known as codethyline and dionine) is an opioid analgesic. Ethylmorphine can be metabolized to form morphine by cytochrome P450 2D6 (CYP2D6). … Morphine can also bind and inhibit gamma-Aminobutyric acid (GABA) inhibitory interneurons.
Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium channel protein type 10 subunit alphaPentazocine Action Pathway
smpdb.ca/view/SMP0000686Drug actionBinding of pentazocine on mu-type opioid receptor and kappa-type opioid receptor can lead to decreased level of neuronal excitability and hyperpolarization. … Pentazocine can bind to mu-type opioid receptor and kappa-type opioid receptor on neuron of central nerves system (CNS).
Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium channel protein type 10 subunit alphaBenzocaine Action Pathway
smpdb.ca/view/SMP0000392Drug actionOnce inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side. … Benzocaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Benzocaine diffuses across the neuronal plasma membrane in its uncharged base form.
Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium channel protein type 10 subunit alphaMepivacaine Action Pathway
smpdb.ca/view/SMP0000399Drug actionOnce inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side. … Mepivacaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Mepivacaine diffuses across the neuronal plasma membrane in its uncharged base form.
Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium channel protein type 10 subunit alpha