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Arbutamine Action Pathway
smpdb.ca/view/SMP0000664Drug actionArbutamine has nonselective beta and weak alpha-1-adrenergic activity which causes increased chronotropic activity (increase in heart rate) and inotropic activity (increase myocardial contractility). … The system monitors heart rate and blood pressure throughout infusion with alarms for physiological changes or problems.
Enzymes: Potassium channel subfamily K member 1, Inward rectifier potassium channel 4Bevantolol Action Pathway
smpdb.ca/view/SMP0000668Drug actionThis results in a decrease in preload and blood pressure. … Bevantolol is an antagonist of beta-1 adrenoreceptors to block the G protein signalling cascade and inhibit epinephrine induced sympathetic activation such as, increased heart rate.
Enzymes: Potassium channel subfamily K member 1, Inward rectifier potassium channel 4Kidney Function - Collecting Duct
smpdb.ca/view/SMP0121011PhysiologicalIn addition, sodium and potassium are also reabsorbed back into the systemic circulation at the collecting duct via potassium and sodium channels. … As a result, a high concentration of sodium and potassium in the blood vessels occurs. Some urea and other ions may be reabsorbed as well.
Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1Omeprazole Action Pathway (old)
smpdb.ca/view/SMP0000226Drug actionThis active metabolite then binds covalently to the potassium-transporting ATPase protein subunits, found at the secretory surface of the gastric parietal cell, preventing any stimulus. … Losec and Zegerid, is a proton pump inhibitor (PPI) class drug that suppresses the final step in gastric acid production, and was the first proton pump inhibitor to e developed.
Enzymes: Potassium-transporting ATPase alpha chain 1, Potassium-transporting ATPase subunit betaLansoprazole Action Pathway (old)
smpdb.ca/view/SMP0000227Drug actionThis active metabolite then binds covalently to the potassium-transporting ATPase protein subunits, found at the secretory surface of the gastric parietal cell, preventing any stimulus. … In this pathway, lansoprazole is taken orally and is oxidized in the stomach to form the active metabolite of lansoprazole.
Enzymes: Potassium-transporting ATPase alpha chain 1, Potassium-transporting ATPase subunit betaRanitidine Action Pathway
smpdb.ca/view/SMP0000230Drug actionThe potassium transporting ATPase also converts water and ATP to a phosphate molecule and ADP. Alongside the transporters, potassium is brought into the cell. … , and muscarinic acetylcholine receptor M3 which are activated by histamine, gastrin and acetylcholine, respectively.
Enzymes: Potassium-transporting ATPase alpha chain 1, Potassium-transporting ATPase subunit betaFamotidine Action Pathway
smpdb.ca/view/SMP0000231Drug actionBinding of famotidine can effectively inhibit the histamine effects, which lead to reduced nocturnal gastric acid and basal secretion; it can also decrease gastric volume, gastric acid and acidity. … Famotidine (also known as Pepcid) can bind and inhibit histamine H2 receptor on parietal cell's basolateral membrane.
Enzymes: Potassium-transporting ATPase alpha chain 1, Potassium-transporting ATPase subunit betaCimetidine Action Pathway
smpdb.ca/view/SMP0000232Drug actionCimetidine also helps to block pepsin and gastrin output, and due to the inhibition of gastric acid secretion, it is typically used to treat heartburn and ulcers. … This blocks histamine effects, resulting in reduced gastric acid secretion and a reduction in gastric volume and acidity.
Enzymes: Potassium-transporting ATPase alpha chain 1, Potassium-transporting ATPase subunit betaGastric Acid Production
smpdb.ca/view/SMP0000589PhysiologicalMoreover, the chloride and potassium ions are transported into the stomach lumen through their own channels so that hydrogen ions and/or potassium ions can form an ionic bond with chloride ions to form … However, it is also constituted of potassium chloride (KCl) and sodium chloride (NaCl).
Enzymes: Potassium-transporting ATPase alpha chain 1, Potassium-transporting ATPase subunit betaAmiodarone Action Pathway
smpdb.ca/view/SMP0000665Drug actionThe drug inhibits Na,K-activated myocardial adenosine triphosphatase, calcium and potassium channels and beta adrenergic receptors causing an increase in ventricular and atrial muscle action duration. … Amiodarone, trade name Cordarone and Nexterone, is an antianginal and a class III antiarrhythmic drug prescribed to treat irregular heart rhythms.
Enzymes: Potassium channel subfamily K member 1, Inward rectifier potassium channel 4