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Displaying results 191 - 200 of 597 in total
  1. Pathway

    Cimetidine H2 Anti-Histamine Action Pathway

    smpdb.ca/view/SMP0123152
    Drug action

    Cimetidine is an H2 receptor antagonist drug that is mainly used to treat peptic ulcers and heartburns. … It works by acting as a competitive inhibitor and blocks the action of histamine on Histamine H2 receptors.

    Drugs: ATP · Cimetidine · Potassium cation · Magnesium cation · Zinc · Cyclic adenosine monophosphate
    Enzymes: Chloride anion exchanger, Potassium-transporting ATPase alpha chain 1
  2. Pathway

    Procainamide Action Pathway (New)

    smpdb.ca/view/SMP0126265
    Drug action

    Procainamide mainly inhibits sodium channels protein type 5 subunit alpha but also inhibits the potassium voltage gated channel subfamily H member 2. … The main antidysrythmIc effect is mediated through the sodium channel blockage though.

    Drugs: Procainamide · Potassium cation · Calcium · Cyclic adenosine monophosphate
    Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, Sodium channel protein type 5 subunit alpha
  3. Pathway

    Quinidine Action Pathway (New)

    smpdb.ca/view/SMP0126282
    Drug action

    It prolongs cellular action potential by blocking sodium and potassium currents. … Quinidine also reduces repolarizing K+ currents (IKr, IKs), the inward rectifier potassium current (IK1), and the transient outward potassium current Ito, as well as the L-type calcium current ICa and

    Drugs: Quinidine · Potassium cation · Calcium · Cyclic adenosine monophosphate
    Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, Sodium channel protein type 5 subunit alpha
  4. Pathway

    Mexiletine Action Pathway (New)

    smpdb.ca/view/SMP0126263
    Drug action

    It works as a non-selective voltage-gated sodium channel blocker and belongs to the Class IB group of anti-arrhythmic medications. … Mexiletine, like lidocaine, inhibits the inward sodium current required for the initiation and conduction of impulses, thus reducing the rate of rise of the action potential, Phase 0.

    Drugs: Mexiletine · Potassium cation · Calcium · Cyclic adenosine monophosphate
    Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, Sodium channel protein type 5 subunit alpha
  5. Pathway

    Moricizine Action Pathway

    smpdb.ca/view/SMP0126950
    Drug action

    Moricizine is an antiarrhythmic used to treat arrhythmias (irregular heartbeats) and to maintain normal heart rate. it acts on heart muscles by inhibiting inward sodium channels. … This results in a slowed atrioventricular nodal and His-Purkinje conduction, which decreases excitability conduction velocity, and automaticity.

    Drugs: Moricizine · Potassium cation · Calcium · Cyclic adenosine monophosphate
    Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, Sodium channel protein type 5 subunit alpha
  6. Pathway

    Ajmaline Action Pathway

    smpdb.ca/view/SMP0126271
    Drug action

    Ajmaline produces potent sodium channel blocking effects and a very short half-life which makes it a very useful drug for acute intravenous treatments. … This drug in particular has a high affinity for the Nav 1.5 sodium channel. Some side effects of using ajmaline may include warm flushes, tingling skin, vertigo, and eye twitches.

    Drugs: Potassium cation · Calcium · Ajmaline · Cyclic adenosine monophosphate
    Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, Sodium channel protein type 5 subunit alpha
  7. Pathway

    Propafenone Action Pathway

    smpdb.ca/view/SMP0126275
    Drug action

    In Purkinje fibers, and to a lesser extent myocardial fibers, propafenone reduces the fast inward current carried by sodium ions, which is responsible for the drugs antiarrhythmic actions. … Diastolic excitability threshold is increased and effective refractory period prolonged. Propafenone reduces spontaneous automaticity and depresses triggered activity.

    Drugs: Propafenone · Potassium cation · Calcium · Cyclic adenosine monophosphate
    Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, Sodium channel protein type 5 subunit alpha
  8. Pathway

    Ranolazine Action Pathway

    smpdb.ca/view/SMP0126279
    Drug action

    Electrolyte balance of sodium and potassium is necessary for maintaining normal cardiac contraction and relaxation. … Disruption of adequate sodium and potassium electrolyte balance leads to excessively high concentrations of sodium and calcium, which likely interferes with oxygen supply to the heart muscle.

    Drugs: Ranolazine · Potassium cation · Calcium · Cyclic adenosine monophosphate
    Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, Sodium channel protein type 5 subunit alpha
  9. Pathway

    Disopyramide Cardiac Action Pathway

    smpdb.ca/view/SMP0126247
    Drug action

    It can be found under the brand names Norpace and Rythmodan. … It also possesses some anticholinergic and local anesthetic properties.

    Drugs: Disopyramide · Potassium cation · Calcium · Cyclic adenosine monophosphate
    Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, Sodium channel protein type 5 subunit alpha
  10. Pathway

    Diltiazem Calcium Channel Cardiac Muscle Relaxation Action Pathway

    smpdb.ca/view/SMP0126292
    Drug action

    This effect is thought to be mediated by the voltage-dependent block of the L-type calcium channels and inhibition of calcium ion release from the ER stores, without altering the sodium-calcium coupled … the coronary and systemic arteries, including epicardial and subendocardial.

    Drugs: Diltiazem · Potassium cation · Calcium · Cyclic adenosine monophosphate
    Enzymes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, Sodium channel protein type 5 subunit alpha