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The Oncogenic Action of 2-Hydroxyglutarate
smpdb.ca/view/SMP0002291Disease2-Hydroxyglutarate is a compound formed from isocitric acid, a component of the TCA cycle. Isocitric acid becomes dehydrogenated by isocitrate dehydrogenase using NADP as a cofactor, and forming oxoglutaric acid. Oxoglutaric acid then fo...
Enzymes: Malate dehydrogenase, mitochondrial2-Ketoglutarate Dehydrogenase Complex Deficiency
smpdb.ca/view/SMP0125755Disease2-Ketoglutarate dehydrogenase complex deficiency, also known as alpha-ketoglutarate dehydrogenase deficiency or oxoglutaric aciduria, is an autosomal recessive disorder of the Krebs cycle caused by a defective oxoglutarate dehydrogenase ...
Enzymes: Malate dehydrogenase, mitochondrialPyruvate Dehydrogenase Deficiency (E3)
smpdb.ca/view/SMP0125756DiseaseDihydrolipoamide dehydrogenase deficiency, which is also known as DLDD, DLD, E3 deficiency, pyruvate dehydrogenase E3 deficiency, DLD deficiency, E3-deficient maple syrup urine disease, is a rare inherited inborn error of metabolism. DLD...
Enzymes: Malate dehydrogenase, mitochondrialThe Oncogenic Action of Succinate
smpdb.ca/view/SMP0002292DiseaseHypoxia-inducible factor In many tumours, oxygen availability becomes limited (hypoxia) very quickly during cancer development. The major regulator of the response to hypoxia is the HIF transcription factor. Under normal oxygen levels, t...
Enzymes: Malate dehydrogenase, mitochondrialOligospermia
go.drugbank.com/conditions/DBCOND0001337Drugs: MesteroloneSynonyms: Male Infertility Due to HypospermatogenesisHydrocodone
go.drugbank.com/drugs/DB00956ApprovedIllicitInvestigationalHydrocodone is a synthetic opioid derivative of codeine. It is commonly used in combination with acetaminophen to control moderate to severe pain. Historically, hydrocodone has been used as a cough suppressant although this has largely b...
Mixtures: Hydrocodone Bitartrate and Chlorpheniramine Maleate, Hydrocodone Bitartrate and Chlorpheniramine Maleate SolutionThe Oncogenic Action of L-2-Hydroxyglutarate in Hydroxyglutaric aciduria
smpdb.ca/view/SMP0002358DiseaseHydroxyglutaric aciduria is a rare genetic disorder. Both isoforms are believed to have autosomal recessive inheritance. The compound 2-hydroxyglutarate is the product of gain-of-function mutations producing mutIDH1 and mutIDH2 in the cy...
Enzymes: Malate dehydrogenase, mitochondrialHypergonadotropic Hypogonadism
go.drugbank.com/conditions/DBCOND0048343Drugs: Fluoxymesterone · Methyltestosterone · Testosterone · Testosterone cypionate · Testosterone enanthateSynonyms: Primary male hypogonadismThe Oncogenic Action of Fumarate
smpdb.ca/view/SMP0002295DiseaseHypoxia-inducible factor In many tumours, oxygen availability becomes limited (hypoxia) very quickly during cancer development. The major regulator of the response to hypoxia is the HIF transcription factor. Under normal oxygen levels, t...
Enzymes: Malate dehydrogenase, mitochondrialThe Oncogenic Action of D-2-Hydroxyglutarate in Hydroxyglutaric aciduria
smpdb.ca/view/SMP0002359DiseaseHydroxyglutaric aciduria is a rare genetic disorder. Both isoforms are believed to have autosomal recessive inheritance. The compound 2-hydroxyglutarate is the product of gain-of-function mutations producing mutIDH1 and mutIDH2 in the cy...
Enzymes: Malate dehydrogenase, mitochondrial