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Displaying results 2011 - 2020 of 10000 in total
  1. Drug

    Dexpanthenol

    go.drugbank.com/drugs/DB09357
    ApprovedInvestigational

    Dexpanthenol is enzymatically cleaved to form pantothenic acid, which is an essential component of Coenzyme A, which acts as a cofactor in many enzymatic reactions that are important for protein metabolism … in the epithelium[A32373].

    Mixtures: Alsimine W Vitamins A D, Alsimine W Vitamins A DCategories: Vitamin D and Analogues, Preparations for Treatment of Wounds and Ulcers
  2. Target

    Serine/threonine-protein kinase Nek9

    go.drugbank.com/bio_entities/BE0009500
    TargetHumans

    Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation (PubMed:12101123, PubMed:12840024, PubMed:14660563, PubMed:19941817).

    Synonyms: Never in mitosis A-related kinase 9
  3. Drug

    Chlorprothixene

    go.drugbank.com/drugs/DB01239
    ApprovedInvestigationalWithdrawn

    Chlorprothixene is a typical antipsychotic drug of the thioxanthene (tricyclic) class. … Chlorprothixene exerts strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors.

    Categories: Dopamine D2 Receptor Antagonists, P-glycoprotein inhibitors
  4. Drug

    Sodium phosphate, dibasic

    go.drugbank.com/drugs/DB14502
    ApprovedInvestigational

    Synonyms: Phosphoric acid, sodium salt (1:2)Mixtures: Aminosyn II 7% M In 10% Dextrose(dual Chamber), Aminosyn II 8.5% M In 20% Dextrose (dual Chamber)
  5. Target

    Serine/threonine-protein kinase Nek2

    go.drugbank.com/bio_entities/BE0003796
    TargetHumans

    Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. … Involved in the regulation of centrosome disjunction (PubMed:26220856).

    Synonyms: Never in mitosis A-related kinase 2
  6. Target

    Splicing factor 1

    go.drugbank.com/bio_entities/BE0009118
    TargetHumans

    Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor

    Synonyms: Zinc finger gene in MEN1 locus
  7. Drug

    Axicabtagene ciloleucel

    go.drugbank.com/drugs/DB13915
    ApprovedInvestigational

    The drug has a unique mechanism of action, as it utilizes the patient's own T cells, which play a central role in immune response to cancer. … It is marketed under the brand name Yescarta and is used to treat large B-cell lymphomas and follicular lymphoma in adults.

    Categories: Antigens, Differentiation, B-Lymphocyte, Genetically-modified Autologous T CellsSynonyms: Autologous T cells transduced with retroviral vector encoding an anti-CD-19 CD28/CD3-zeta chimeric antigen receptor
  8. Drug

    Idelalisib

    go.drugbank.com/drugs/DB09054
    ApprovedInvestigational

    For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination with rituximab in patients for whom rituximab alone would be considered appropriate therapy due to other … The PI-3Ks are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer

    Synonyms: 5-Fluoro-3-phenyl-2-((S)-1-(9H-purin-6-ylamino)-propyl)-3H-quinazolin-4-one, 5-fluoro-3-phenyl-2-[(1S)-1-(3H-purin-6-ylamino)propyl]quinazolin-4(3H)-oneCategories: Class Ia Phosphatidylinositol 3-Kinase, antagonists & inhibitors, P-glycoprotein substrates with a Narrow Therapeutic Index
  9. Drug

    Spirapril

    go.drugbank.com/drugs/DB01348
    ApprovedInvestigational

    ACE inhibitors are used primarily in treatment of hypertension and congestive heart failure. … Spirapril is an ACE inhibitor antihypertensive drug used to treat hypertension. Spirapril is converted to the active spiraprilat after administration.

    Categories: Agents Acting on the Renin-Angiotensin System
  10. Drug

    Poliovirus type 1 antigen (formaldehyde inactivated)

    go.drugbank.com/drugs/DB10795
    ApprovedInvestigational

    Poliovirus type 1 antigen is a suspension of poliovirus Type 1 (Mahoney) used in the active immunization of infants (as young as 6 weeks of age), children, and adults for the prevention of poliomyelitis … The vaccine contains purified and inactivated poliovirus type 1 that were grown from a continuous line of monkey kidney cells.

    Mixtures: Dt Polio Adsorbed - Sus Im, VeroPol Injektionslösung in einer FertigspritzeSynonyms: Inactivated poliovirus type I, poliovirus vaccine inactivated, type 1 (Mahoney)