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Ipilimumab
go.drugbank.com/drugs/DB06186ApprovedInvestigationalIpilimumab is a fully humanized IgG1 monoclonal antibody that blocks cytotoxic T lymphocyte antigen-4 (CTLA-4). Blocking CTLA-4 removes an inhibitory signal from reducing the activity of T lymphocytes. Ipilimumab was developed by Bristol...
VT-111
go.drugbank.com/drugs/DB05646InvestigationalVT-111 is a 55 kDa secreted glycoprotein belonging to a superfamily of proteins called SERPINS, which share a general structure and mechanism for proteinase inhibition.
Solute carrier family 52, riboflavin transporter, member 2
go.drugbank.com/bio_entities/BE0004841TargetTransporterHumansHumans are unable to synthesize vitamin B2/riboflavin and must obtain it via intestinal absorption (PubMed:20463145). May also act as a receptor for 4-hydroxybutyrate (Probable)
Synonyms: PERV-A receptor 1, Porcine endogenous retrovirus A receptor 1Function: 4-hydroxybutyrate receptor activityHydroxyurea
go.drugbank.com/drugs/DB01005ApprovedInvestigationalHydroxyurea is a non-alkylating antineoplastic agent that was first synthesized in 1869 but was not characterized biologically until 1928. It was first approved by the FDA in 1998 for the treatment of sickle cell anemia in adults. Althou...
Categories: Cytochrome P-450 CYP2D6 Inhibitors, Cytochrome P-450 Enzyme InhibitorsVinorelbine
go.drugbank.com/drugs/DB00361ApprovedInvestigationalVinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC) . It was initially approved in the USA in 1990's for the trea...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 InhibitorsP2Y purinoceptor 12
go.drugbank.com/bio_entities/BE0000110TargetHumansReceptor for ADP and ATP coupled to G proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Required for normal platelet aggregation and blood coagulation
Synonyms: ADP-glucose receptor, P2Y12 platelet ADP receptorFunction: G protein-coupled adenosine receptor activityGrowth arrest-specific protein 6
go.drugbank.com/bio_entities/BE0010201TargetHumansLigand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell su...
Synonyms: AXL receptor tyrosine kinase ligandVPM1002
go.drugbank.com/drugs/DB15801InvestigationalBy reducing urease C, phagosome acidification can occur, promoting phagolysosome fusion while also providing the optimal low pH for listeriolysin O stability. … Because Hly is only active at an acidic pH, similar to listeriolysin O, the deletion of urease C was also beneficial for Hly to have optimal bioactivity in the phagosome.
Galactose
go.drugbank.com/drugs/DB11735ApprovedInvestigationalWithdrawnGalactose has been used in trials studying the treatment and diagnosis of Hepatitis C, Hepatic Cancer, Wilsons Disease, Diabetic Macular Oedema, and Focal Segmental Glomerulosclerosis, among others. There are even proposals for its use i...
T-cell surface glycoprotein CD3
go.drugbank.com/bio_entities/BE0010202TargetHumansAlso participates in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region (PubMed:10384095, PubMed:26507128). … In addition to its role as a TCR coreceptor, it serves as a receptor for ITPRIPL1 (PubMed:38614099).
Synonyms: T-cell receptor T3 delta chain, T-cell receptor T3 zeta chain