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Dupilumab
go.drugbank.com/drugs/DB12159ApprovedInvestigationalDupilumab is a fully human monoclonal antibody of the immunoglobulin G4 subclass that binds to the interleukin-4 (IL-4) receptor, inhibiting the receptor signaling pathways. … [A180478] As an interleukin-4 receptor alpha antagonist, dupilumab inhibits the signaling of pro-inflammatory cytokines, called interleukins (IL), that induce inflammatory and immunological reactions in
Categories: Interleukin-4 Receptor alpha Antagonist, Interleukin 4 Receptor alpha AntagonistsT-lymphocyte activation antigen CD80
go.drugbank.com/bio_entities/BE0000847TargetHumansAlso acts as an inhibitor of T-cell activation by acting as a ligand for CTLA4, a decoy receptor, thereby blocking CD28-mediated T-cell priming (PubMed:10583602, PubMed:11279502). … Acts as the primary auxiliary signal augmenting the MHC/TCR signal in naive T-cells by acting as a ligand for the CD28 receptor which is constitutively expressed on the cell surface of T-cells (PubMed:
Synonyms: CTLA-4 counter-receptor B7.1Small ribosomal subunit protein RACK1
go.drugbank.com/bio_entities/BE0008967TargetHumansRegulates internalization of the muscarinic receptor CHRM2. Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L.
Synonyms: Receptor for activated C kinase, Receptor for activated C kinase 1Lecithin, soybean
go.drugbank.com/drugs/DB14161InvestigationalA complex mixture of phospholipids; glycolipids; and triglycerides; with substantial amounts of phosphatidylcholines; phosphatidylethanolamines; and phosphatidylinositols, which are sometimes loosely termed as 1,2-diacyl-3-phosphocholine...
Mixtures: GNC PP AA FormulaT-lymphocyte activation antigen CD86
go.drugbank.com/bio_entities/BE0000846TargetHumansAlso acts as an inhibitor of T-cell activation by acting as a ligand for CTLA4, a decoy receptor, thereby blocking CD28-mediated T-cell priming (PubMed:11279501) … Acts as the primary auxiliary signal augmenting the MHC/TCR signal in naive T-cells by acting as a ligand for the CD28 receptor which is constitutively expressed on the cell surface of T-cells (PubMed:
Synonyms: CTLA-4 counter-receptor B7.2Integrin beta-1
go.drugbank.com/bio_entities/BE0003575TargetHumansIntegrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. … ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430).
Synonyms: Fibronectin receptor subunit betaSerine/threonine-protein kinase TNNI3K
go.drugbank.com/bio_entities/BE0009401TargetHumansMay play a role in cardiac physiology
Synonyms: Cardiac ankyrin repeat kinaseZinc cation
go.drugbank.com/drugs/DB14532InvestigationalMixtures: Orajel 4X Medicated PM For Toothache and GumProtein arginine N-methyltransferase 1
go.drugbank.com/bio_entities/BE0004597TargetHumansMay be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator
Synonyms: Interferon receptor 1-bound protein 4Stabilin-2
go.drugbank.com/bio_entities/BE0004948TargetHumansPhosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). … Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature.
Synonyms: Hyaluronan receptor for endocytosis, Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2