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Depemokimab
go.drugbank.com/drugs/DB18846ApprovedInvestigationalDepemokimab is a humanized Immunoglobulin G1 (IgG1) monoclonal antibody and a long-acting drug. … [A275338, L54758] Its long duration of action is granted by seven amino acid substitutions in the heavy chain sequence.
Categories: Interleukin-5 AntagonistSynonyms: Immunoglobulin g1, anti-(human interleukin 5) (human-mus musculus monoclonal gsk3511294 .gamma.1-chain), disulfide with human-mus musculus monoclonal gsk3511294 .kappa.-chain, dimerNeisseria meningitidis serogroup B recombinant LP2086 B01 protein variant antigen
go.drugbank.com/drugs/DB10285ApprovedInvestigationalIt is contained in the suspension of Trumenba, which is a vaccine is composed of two recombinant lipidated factor H binding protein (fHBP) variants from N. meningitidis serogroup B, one from fHBP subfamily … Neisseria meningitidis serogroup b recombinant lp2086 b01 protein variant antigen is a sterile vaccine for intramuscular injection indicated for the active immunization to prevent invasive disease caused
Synonyms: Neisseria meningitidis serogroup B recombinant LP2086 B01 protein variant antigenMixtures: TRUMENBA SUSPENSION FOR INJECTION IN SINGLE-DOSE PRE-FILLED SYRINGE 0.5MLAmiodarone Action Pathway (New)
smpdb.ca/view/SMP0122646Drug actionIn the presence of amiodarone, K+ accumulates in the cell since the potassium channels are blocked by amiodarone.
Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2Dofetilide Action Pathway
smpdb.ca/view/SMP0126189Drug actionIn the presence of dofetilide, K+ accumulates in the cell since the potassium channels are blocked by the drug (rectifier potassium current). … This drug is used for the maintenance of normal sinus rhythm and cardioversion in cases of atrial fibrillation and atrial flutter.
Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2Ajmaline Action Pathway
smpdb.ca/view/SMP0126271Drug actionThe drug has been very popular in some countries for the treatment of atrial fibrillation in patients with the Wolff–Parkinson–White syndrome and in well tolerated monomorphic ventricular tachycardias. … An alkaloid found in the root of Rauwolfia serpentina, among other plant sources.
Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2Propafenone Action Pathway
smpdb.ca/view/SMP0126275Drug actionThe electrophysiological effect of propafenone manifests itself in a reduction of upstroke velocity (Phase 0) of the monophasic action potential. … Used to prolong the time to recurrence of paroxysmal atrial fibrillation/flutter (PAF) associated with disabling symptoms in patients without structural heart disease.
Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2Quinidine Action Pathway (New)
smpdb.ca/view/SMP0126282Drug actionA phenomenon known as “quinidine syncope” was first described in the 1950s, characterized by syncopal attacks and ventricular fibrillation in patients treated with this drug. … This alkaloid was first described in 1848 and has a long history as an antiarrhythmic medication.
Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2Pivmecillinam
go.drugbank.com/drugs/DB01605ApprovedInvestigationalPivmecillinam is a mecillinam prodrug, a pivaloyloxymethyl ester of amdinocillin that is well absorbed orally, but broken down to amdinocillin in the intestinal mucosa. … It is active against gram-negative organisms and used as for amdinocillin. [PubChem]
Categories: Heterocyclic Compounds, 2-RingPiroxicam Action Pathway
smpdb.ca/view/SMP0000077Drug actionDecreased prostaglandin synthesis in many animal model's cell is caused by presence of piroxicam. … Prostaglandin G/H synthase 1 and 2 catalyze the arachidonic acid to prostaglandin G2, and also catalyze prostaglandin G2 to prostaglandin H2 in the metabolism pathway.
Enzymes: Prostaglandin E synthaseEtodolac Action Pathway
smpdb.ca/view/SMP0000084Drug actionThis in turn inhibits the calcium-dependent events, including PLA2 activation, involved in platelet activation and aggregation. … COX-1 activity in platelets is required for thromboxane A2 (TxA2)-mediated platelet aggregation. Platelet activation and coagulation do not normally occur in intact blood vessels.
Enzymes: Prostaglandin E synthase