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Rofecoxib Action Pathway
smpdb.ca/view/SMP0000087Drug actionThis in turn inhibits the calcium-dependent events, including PLA2 activation, involved in platelet activation and aggregation. … COX-1 activity in platelets is required for thromboxane A2 (TxA2)-mediated platelet aggregation. Platelet activation and coagulation do not normally occur in intact blood vessels.
Enzymes: Prostaglandin E synthaseDiclofenac Action Pathway
smpdb.ca/view/SMP0000093Drug actionProstaglandin G/H synthase 1 and 2 catalyze the arachidonic acid to prostaglandin G2, and also catalyze prostaglandin G2 to prostaglandin H2 in the metabolism pathway.
Enzymes: Prostaglandin E synthaseKetorolac Action Pathway
smpdb.ca/view/SMP0000098Drug actionProstaglandin G/H synthase 1 and 2 catalyze the arachidonic acid to prostaglandin G2, and also catalyze prostaglandin G2 to prostaglandin H2 in the metabolism pathway. … Since prostaglandin is the messenger molecules in the process of inflammation; hence, inhibition of prostaglandin synthesis can reduce the pain, fever and inflammation.
Enzymes: Prostaglandin E synthaseSuprofen Action Pathway
smpdb.ca/view/SMP0000101Drug actionSince prostaglandin is the messenger molecules in the process of inflammation; hence, inhibition of prostaglandin synthesis can reduce the pain and inflammation (e.g. in the eyes). … Prostaglandin G/H synthase 1 and 2 catalyze the arachidonic acid to prostaglandin G2, and also catalyze prostaglandin G2 to prostaglandin H2 in the metabolism pathway.
Enzymes: Prostaglandin E synthaseNabumetone Action Pathway
smpdb.ca/view/SMP0000114Drug actionProstaglandin G/H synthase 1 and 2 catalyze the arachidonic acid to prostaglandin G2, and also catalyze prostaglandin G2 to prostaglandin H2 in the metabolism pathway. … Since prostaglandin is the messenger molecules in the process of inflammation; hence, inhibition of prostaglandin synthesis can reduce the pain, fever and inflammation.
Enzymes: Prostaglandin E synthaseValdecoxib Action Pathway
smpdb.ca/view/SMP0000116Drug actionThis in turn inhibits the calcium-dependent events, including PLA2 activation, involved in platelet activation and aggregation. … COX-1 activity in platelets is required for thromboxane A2 (TxA2)-mediated platelet aggregation. Platelet activation and coagulation do not normally occur in intact blood vessels.
Enzymes: Prostaglandin E synthaseLeukotriene C4 Synthesis Deficiency
smpdb.ca/view/SMP0000353DiseaseA defect in LTC4 results in decreased concentrations of cysteinyl leukotrienes LTC4, LTD4 and LTE4 in plasma, spinal fluid and urine. … Leukotriene C4 synthetase deficiency is caused by a defect in the enzyme leukotriene C4 synthetase (LTC4S).
Enzymes: Prostaglandin E synthaseAntipyrine Action Pathway
smpdb.ca/view/SMP0000692Drug actionDecreased prostaglandin synthesis in many animal model's cell is caused by presence of antipyrine. … Antipyrine (also named Fenazone or Phenazone) is often used for testing the effect of other drugs on drug-metabolizing enzymes in the liver.
Enzymes: Prostaglandin E synthaseAntrafenine Action Pathway
smpdb.ca/view/SMP0000693Drug actionDecreased prostaglandin synthesis in many animal model's cell is caused by presence of antrafenine. … Prostaglandin G/H synthase 1 and 2 catalyze the arachidonic acid to prostaglandin G2, and also catalyze prostaglandin G2 to prostaglandin H2 in the metabolism pathway.
Drugs: Glutamic acid · Glutathione · Dinoprostone · Calcium · Magnesium cation · Antrafenine +5 moreEnzymes: Prostaglandin E synthaseCarprofen Action Pathway
smpdb.ca/view/SMP0000694Drug actionDecreased prostaglandin synthesis in many animal model's cell is caused by presence of Carprofen. … Prostaglandin G/H synthase 1 and 2 catalyze the arachidonic acid to prostaglandin G2, and also catalyze prostaglandin G2 to prostaglandin H2 in the metabolism pathway.
Enzymes: Prostaglandin E synthase