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Displaying results 2321 - 2330 of 10000 in total
  1. Pathway

    Penbutolol Action Pathway

    smpdb.ca/view/SMP0000305
    Drug action

    Penbutolol can also bind beta-2 adrenergic receptors in juxtaglomerular apparatus and bronchiole smooth muscle. … In bronchiole smooth muscle, binding of penbutolol to beta-2 adrenergic receptors can also prevent vasoconstriction.

    Drugs: ATP · Potassium cation · Penbutolol · Calcium
    Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2
  2. Pathway

    Lidocaine (Antiarrhythmic) Action Pathway

    smpdb.ca/view/SMP0000328
    Drug action

    This pathway illustrates the lidocaine targets involved in antiarrhythmic therapy. … The positive outflow of potassium ions aids in maintaining the negative intracellular electric potential.

    Drugs: NADH · ATP · Lidocaine · Potassium cation · Calcium · Mesoheme +1 more
    Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2
  3. Pathway

    Mexiletine Action Pathway

    smpdb.ca/view/SMP0000329
    Drug action

    This pathway illustrates the mexiletine targets involved in antiarrhythmic therapy. … The positive outflow of potassium ions aids in maintaining the negative intracellular electric potential.

    Drugs: ATP · Mexiletine · Potassium cation · Calcium
    Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2
  4. Pathway

    Carvedilol Action Pathway

    smpdb.ca/view/SMP0000367
    Drug action

    Carvedilol, trade name Coreg, is a nonselective beta-blocker that blocks both alpha and beta receptors of the heart and blood vessels. It is prescribed to treat hypertension, stable angina pectoris and congestive heart failure. Carvedilo...

    Drugs: ATP · Carvedilol · Potassium cation · Calcium
    Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2
  5. Pathway

    Amlodipine Action Pathway

    smpdb.ca/view/SMP0000376
    Drug action

    The net effect is decreased contractility of arterial smooth muscle and increased vasodilation resulting in a decrease in blood pressure.

    Drugs: ATP · Amlodipine · Potassium cation · Calcium
    Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2
  6. Pathway

    Nitrendipine Action Pathway

    smpdb.ca/view/SMP0000382
    Drug action

    Nitrendipine binds the major channel in muscle cells: L-type calcium channels. … Lack of initial influx of calcium can also reduce the level of contractile activity of muscle cells and results in vasodilation, which ultimately lead to overall decresing in blood pressure.

    Drugs: ATP · Nitrendipine · Potassium cation · Calcium
    Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2
  7. Pathway

    Striated Muscle Contraction

    smpdb.ca/view/SMP0000588
    Physiological

    These functional units, in turn, are composed of many alternating actin and mysoin protein filaments that produce muscle contraction.

    Drugs: ATP · Potassium cation · Calcium
    Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2
  8. Pathway

    Bupranolol Action Pathway

    smpdb.ca/view/SMP0000670
    Drug action

    It competes with catecholamines for binding beta-1 adrenergic receptors in the heart to inhibit sympathetic activation. This inhibition causes decreased heart rate, cardiac output, blood pressure

    Drugs: ATP · Potassium cation · Calcium · Bupranolol
    Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2
  9. Drug

    Pirfenidone

    go.drugbank.com/drugs/DB04951
    ApprovedInvestigational

    Pirfenidone is a synthetic pyridone drug. … [A251370] It is an antifibrotic agent with anti-inflammatory and antioxidant properties [A251370] that is used to treat idiopathic pulmonary fibrosis (IPF),[L26801] which is a chronic, progressive form

    Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesProducts: PIRFENIDONE EG, S
  10. Drug

    Alcloxa

    go.drugbank.com/drugs/DB11205
    Approved

    Mixtures: BIS II Tooth, BIS II Tooth