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Displaying results 2371 - 2380 of 8696 in total
  1. Drug

    Lacosamide

    go.drugbank.com/drugs/DB06218
    ApprovedInvestigational

    Lacosamide is an antiepileptic drug used to treat seizures. As a chiral functionalized amino acid, it works by blocking slowly inactivating components of voltage-gated sodium currents.

    Mixtures: Lacopat-Filmtabletten Packung zur Behandlungseinleitung, Lacopat-Filmtabletten Packung zur BehandlungseinleitungCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
  2. Drug

    Andexanet alfa

    go.drugbank.com/drugs/DB14562
    Approved

    It was developed by Portola Pharmaceuticals and was approved in in May 2018. … However, the use of these agents is associated with a risk for uncontrollable bleeding episodes that can lead to can cause serious or fatal bleeding.

  3. Drug

    Methylphenobarbital

    go.drugbank.com/drugs/DB00849
    Approved

    It has been used for similar purposes, especially in epilepsy, but there is no evidence mephobarbital offers any advantage over phenobarbital.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Inducers
  4. Target

    G protein-coupled receptor kinase 2

    go.drugbank.com/bio_entities/BE0000341
    TargetHumans

    Such receptor phosphorylation initiates beta-arrestin-mediated receptor internalization, and signaling events leading to their desensitization (PubMed:14976224, PubMed:16179383, PubMed:19306925, PubMed … Also able to mediate phosphorylation-independent desensitization of dopamine receptor DRD2 (By similarity)

    Polypeptides: G protein-coupled receptor kinase 2Synonyms: Beta-adrenergic receptor kinase 1
  5. Target

    Receptor tyrosine-protein kinase erbB-2

    go.drugbank.com/bio_entities/BE0000511
    TargetEnzymeHumans

    Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. … Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding.

    Polypeptides: Receptor tyrosine-protein kinase erbB-2Synonyms: Tyrosine kinase-type cell surface receptor HER2
  6. Target

    Taste receptor type 1 member 3

    go.drugbank.com/bio_entities/BE0000582
    TargetHumans

    Functions as a G protein-coupled receptor and primarily signals through the gustducin heterotrimer (PubMed:40339580). … The sweet taste receptor has lower affinity for natural sugars than for synthetic sweeteners (PubMed:40339580, PubMed:40555359).

    Polypeptides: Taste receptor type 1 member 3Synonyms: Sweet taste receptor T1R3
  7. Target

    Insulin-like growth factor 1 receptor

    go.drugbank.com/bio_entities/BE0000858
    TargetHumans

    Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor … In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity.

    Polypeptides: Insulin-like growth factor 1 receptorSynonyms: IGF-I receptor, Insulin-like growth factor I receptor
  8. Target

    C-C chemokine receptor type 5

    go.drugbank.com/bio_entities/BE0000911
    TargetHumans

    May play a role in the control of granulocytic lineage proliferation or differentiation. … Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor (PubMed:30713770)

    Polypeptides: C-C chemokine receptor type 5
  9. Target

    Growth factor receptor-bound protein 2

    go.drugbank.com/bio_entities/BE0000917
    TargetHumans

    Functions also a role in B-cell activation by amplifying Ca(2+) mobilization and activation of the ERK MAP kinase pathway upon recruitment to the phosphorylated B-cell antigen receptor (BCR) (PubMed:25413232 … Controls signaling complexes at the T-cell antigen receptor to facilitate the activation, differentiation, and function of T-cells (PubMed:36864087, PubMed:9489702).

    Polypeptides: Growth factor receptor-bound protein 2Function: ephrin receptor binding
  10. Target

    High affinity nerve growth factor receptor

    go.drugbank.com/bio_entities/BE0001039
    TargetHumans

    In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors … Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and

    Polypeptides: High affinity nerve growth factor receptorSynonyms: Tyrosine kinase receptor, Tyrosine kinase receptor A