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Spesolimab
go.drugbank.com/drugs/DB15626ApprovedInvestigational[A252220, A252225] Spesolimab received recommendations from the EMA's Committee for Medicinal Products for Human Use (CHMP) to be granted marketing authorization in October 2022 and was finally approved … Spesolimab works by inhibiting the inflammatory signaling pathway of IL-36,[L43090] which is often overexpressed and aberrantly overactive in generalized pustular psoriasis.
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsSerine
go.drugbank.com/drugs/DB00133ApprovedInvestigationalNutraceuticalA non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from glycine or threonine. It is involved in the biosynthesis of purines; pyrimidines; and other amino acids.
Mixtures: Aminosyn II and Dextrose, Aminosyn II and DextroseCategories: Amino Acids, Peptides, and ProteinsVaborbactam
go.drugbank.com/drugs/DB12107ApprovedInvestigationalVabomere consists of vaborbactam and [Meropenem] for intravenous administration. … [Label] The treatment aims to resolve infection-related symptoms of cUTI and achieve negative urine culture, when the infections are proven or strongly suspected to be caused by susceptible bacteria.
Categories: meropenem and vaborbactamIdebenone
go.drugbank.com/drugs/DB09081ApprovedInvestigationalthe lipid membrane and mitochondria from oxidative damage [A19768]. … It is not currently approved for use by either the Food and Drug Administration (USA) or Health Canada.
Categories: Enzymes and Coenzymes, Psychostimulants, Agents Used for ADHD and NootropicsLeniolisib
go.drugbank.com/drugs/DB16217ApprovedInvestigational[L45758] APDS is a primary immunodeficiency caused by mutations in genes encoding the PI3Kδ, thereby increasing the activity of PI3Kδ, causing immune dysfunction, and elevating susceptibility to infections … Leniolisib is a potent and selective inhibitor of phosphoinositide 3-kinase δ (PI3Kδ).
Categories: Antineoplastic and Immunomodulating AgentsEntacapone
go.drugbank.com/drugs/DB00494ApprovedInvestigationalof levodopa and a decarboxylase inhibitor. … When administered concomittantly with levodopa and a decarboxylase inhibitor (e.g., carbidopa), increased and more sustained plasma levodopa concentrations are reached as compared to the administration
Mixtures: DOPALEVO 100MG/25MG/200MG FILM KAPLI TABLET ,100TABLET, DOPALEVO 150MG/37.5MG/200MG FILM KAPLI TABLET ,100 TABLETTyphoid Vi polysaccharide vaccine
go.drugbank.com/drugs/DB10803ApprovedInvestigationalIt is an active immunization for the prevention of typhoid fever caused by S typhi and is approved for use in persons two years of age or older. … The bacterial culture is inactivated in the medium with the capsular polysaccharides precipated from the solution.
Pregnancy zone protein
go.drugbank.com/bio_entities/BE0009089TargetHumansFollowing cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase
Synonyms: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6Serine/threonine-protein kinase ATR
go.drugbank.com/bio_entities/BE0010060TargetHumansInvolved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability and catalyzing phosphorylation of LMNA at ' … Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RBBP8, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis (PubMed:11114888, PubMed
Synonyms: Ataxia telangiectasia and Rad3-related proteinVerruca (Warts)
go.drugbank.com/conditions/DBCOND0060939Synonyms: Viral wart of skin and/or mucous membrane caused by human papillomavirus, Viral wart of skin and/or mucous membrane caused by human papillomavirus (disorder)