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Displaying results 2431 - 2440 of 8696 in total
  1. Target

    Gamma-aminobutyric acid receptor subunit theta

    go.drugbank.com/bio_entities/BE0003597
    TargetHumans

    Theta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:10449790, PubMed:16412217). GABA-gated chloride channels, also named GA...

    Polypeptides: Gamma-aminobutyric acid receptor subunit thetaSynonyms: GABA(A) receptor subunit theta
  2. Target

    Gamma-aminobutyric acid receptor subunit delta

    go.drugbank.com/bio_entities/BE0003599
    TargetHumans

    GABAAR containing alpha-4-beta-3-delta subunits can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation

    Polypeptides: Gamma-aminobutyric acid receptor subunit deltaSynonyms: GABA(A) receptor subunit delta
  3. Target

    BDNF/NT-3 growth factors receptor

    go.drugbank.com/bio_entities/BE0003605
    TargetHumans

    May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia … Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4.

    Polypeptides: BDNF/NT-3 growth factors receptorSynonyms: Neurotrophic tyrosine kinase receptor type 2
  4. Target

    Receptor-type tyrosine-protein phosphatase beta

    go.drugbank.com/bio_entities/BE0003769
    TargetHumans

    Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadhe...

    Polypeptides: Receptor-type tyrosine-protein phosphatase beta
  5. Target

    T cell receptor beta constant 1

    go.drugbank.com/bio_entities/BE0003779
    TargetHumans

    Constant region of T cell receptor (TR) beta chain (PubMed:24600447).

    Polypeptides: T cell receptor beta constant 1
  6. Target

    Receptor tyrosine-protein kinase erbB-4

    go.drugbank.com/bio_entities/BE0004772
    TargetHumans

    Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. … Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF.

    Polypeptides: Receptor tyrosine-protein kinase erbB-4Synonyms: Tyrosine kinase-type cell surface receptor HER4
  7. Target

    Membrane-associated progesterone receptor component 1

    go.drugbank.com/bio_entities/BE0004896
    TargetHumans

    Forms a ternary complex with TMEM97 receptor and low density lipid receptor/LDLR, which increases LDLR-mediated LDL lipoprotein internalization (PubMed:30443021) … Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity).

    Polypeptides: Membrane-associated progesterone receptor component 1
  8. Target

    GABA(A) Receptor Benzodiazepine Binding Site

    go.drugbank.com/bio_entities/BE0008668
    TargetHumans

    Together with rho subunits, may also control neuronal and glial GABAergic transmission in the cerebellum (By similarity) … GABAARs function also as histamine receptor where histamine binds at the interface of two neighboring beta subunits and potentiates GABA response (By similarity).

    Polypeptides: Gamma-aminobutyric acid receptor subunit alpha-1, Gamma-aminobutyric acid receptor subunit alpha-2Synonyms: GABA(A) receptor subunit alpha-1, GABA(A) receptor subunit alpha-2
  9. Target

    Taste receptor type 2 member 16

    go.drugbank.com/bio_entities/BE0009016
    TargetHumans

    Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5

    Polypeptides: Taste receptor type 2 member 16Function: bitter taste receptor activity
  10. Target

    Bone morphogenetic protein receptor type-1A

    go.drugbank.com/bio_entities/BE0009272
    TargetHumans

    May promote the expression of HAMP, potentially via its interaction with BMP2 (By similarity) … On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases.

    Polypeptides: Bone morphogenetic protein receptor type-1ASynonyms: BMP type-1A receptor, Activin receptor-like kinase 3