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DNA topoisomerase I, mitochondrial
go.drugbank.com/bio_entities/BE0000091TargetHumansReleases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a t...
Polypeptides: DNA topoisomerase I, mitochondrialTroponin I, cardiac muscle
go.drugbank.com/bio_entities/BE0000656TargetHumansTroponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity
Polypeptides: Troponin I, cardiac muscleSynonyms: Cardiac troponin IOrnithine carbamoyltransferase subunit I
go.drugbank.com/bio_entities/BE0001875TargetEscherichia coli (strain K12)Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline, which is a substrate for argininosuccinate synthetase, the enzyme involved in the f...
Polypeptides: Ornithine carbamoyltransferase subunit ISynonyms: Ornithine carbamoyltransferase chain IHerpes simplex type I reactivation
go.drugbank.com/conditions/DBCOND0025063Drugs: AcyclovirSynonyms: Herpes simplex type I reactivationLevamisole
go.drugbank.com/drugs/DB00848ApprovedInvestigationalVet approvedWithdrawn[A178117] It was manufactured by _Janssen_ and first used in 1969 as an agent to treat worm infestations[A178123] Levamisole was approved by the FDA in 1990 as an adjuvant treatment for colon cancer. … [A178123] Interestingly, levamisole has been found as an adulterant in cocaine and can lead to a variety of adverse effects in individuals using this drug.[A178120]
Categories: Heterocyclic Compounds, 1-RingProducts: OBAT CACING NO.17 KAM CEK SAN, PVP- LEVAMISOLE POUR-ON SOLUTION 20 %w/vBuprenorphine
go.drugbank.com/drugs/DB00921ApprovedIllicitInvestigationalVet approvedCombination with naloxone is intended to reduce the abuse potential of Suboxone, as naloxone is poorly absorbed by the oral route (and has no effect when taken orally), but would reverse the opioid agonist … [A186263,A186266,A186269] Buprenorphine acts as a partial mu-opioid receptor agonist with a high affinity for the receptor, but lower intrinsic activity compared to other full mu-opioid agonists such
Mixtures: SUBOXONE 8 MG/2 MG DILALTI TABLET, 7 ADET, Suboxone 8 mg/2 mg sublingual tabletsCategories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Drugs Used in Opioid DependencePentoxifylline
go.drugbank.com/drugs/DB00806ApprovedInvestigational[A226608] Pentoxifylline has been marketed in Europe since 1972; PTX extended-release tablets sold under the trade name TRENTAL by US Pharm Holdings were first approved by the FDA on Aug 30, 1984, but … A branded product, PENTOXIL, marketed by Upsher-Smith Laboratories, and generic forms marketed by Valeant Pharmaceuticals and APOTEX have been available since the late 1990s.[L30300]
International brands: Ao Le Ni, An Ruo NingMixtures: Betamethasone Dipropionate 0.05% / Minoxidil 5% / Niacinamide 2% / Pentoxifylline 0.5%No initial therapy
go.drugbank.com/conditions/DBCOND0106200Drugs: TelmisartanSynonyms: No initial therapyKeratin, type I cytoskeletal 12
go.drugbank.com/bio_entities/BE0004660TargetHumansStructural component of intermediate filaments in the corneal epithelium. Forms heteropolymers with the type II keratin KRT3, assembling into keratin intermediate filament networks that provide mechanical strength and structural integrit...
Polypeptides: Keratin, type I cytoskeletal 12Eukaryotic initiation factor 4A-I
go.drugbank.com/bio_entities/BE0008973TargetHumansATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome (PubMed:20156963). In the current model of translation initiation, eIF4A unwinds RNA secondary st...
Polypeptides: Eukaryotic initiation factor 4A-ISynonyms: eIF4A-I, eIF-4A-I