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Eteplirsen
go.drugbank.com/drugs/DB06014ApprovedInvestigational[A244930] It is caused by loss-of-function mutations in the DMD gene coding for dystrophin, an essential protein involved in maintaining the structural integrity and function of muscle fibres. … It consists of a six-membered morpholino ring replacing the five-membered ribofuranosyl rings found in natural DNA and RNA.
Categories: Compounds used in a research, industrial, or household setting, Antisense Elements (Genetics)Synonyms: )-1-piperazinyl)-N,N-dimethylphosphonamidate) RNA, (P-deoxy-P-(dimethylamino)](2',3'-dideoxy-2',3'-imino-2',3'-seco)(2'a→5')(C-m5U-C-C-A-A-C-A-m5U-C-A-A-G-G-A-A-G-A-m5U-G-G-C-A-m5U-m5U-m5U-C-m5U-A-G),5'-(P-(4-((2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)carbonylZolasartan
go.drugbank.com/drugs/DB20140ExperimentalZolasartan is a small molecule drug. The usage of the INN stem '-sartan' in the name indicates that Zolasartan is a angiotensin II receptor antagonist, antihypertensive (non-peptidic). … Zolasartan has a monoisotopic molecular weight of 554.05 Da.
Categories: Angiotensin II Type 1 Receptor Blockers, Angiotensin II receptor antagonistsEmtricitabine
go.drugbank.com/drugs/DB00879ApprovedInvestigationalEmtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) indicated for the treatment of HIV infection in adults[L9019] or combined with [tenofovir alafenamide] for the prevention of HIV-1 infection … in high risk adolescents and adults.
Mixtures: EMTRICITABINA E TENOFOVIR DISOPROXIL DOC GENERICI, EMTRICITABINA E TENOFOVIR DISOPROXIL DR. REDDY'SCategories: Antivirals used in combination for the treatment of HIV infections, MATE 1 SubstratesStreptococcus pneumoniae type 18c capsular polysaccharide antigen
go.drugbank.com/drugs/DB10335ApprovedInvestigationalIt is an active immunization for intramuscular or subcutaneous injection against pneumococcal disease such as pneumococcal pneumonia and pneumococcal bacteremia. … Streptococcus pneumoniae type 18c capsular polysaccharide antigen is a vaccine that contains highly purified capsular polysaccharides from the invasive pneumococcal type 18c of *Streptococcus pneumoniae
Mixtures: PNEUMOVAX 23 Injektionslösung in einer Fertigspritze, PNEUMOVAX 23 Injektionslösung in einer DurchstechflaschePatent Blue
go.drugbank.com/drugs/DB13967ApprovedInvestigationalPatent blue is aniline dye and it is one of the most common dyes used.[A32573] It is a sodium or calcium salt of diethylammonium hydroxide inner salt. … Patent blue was developed by Guerbet and approved by Health Canada on December 31, 1979.[L1113] The isomer isosulphan is used in the United States for the same indications than patent blue.[A32574]
Salts: Patent Blue V calcium, Patent Blue V sodiumCategories: Compounds used in a research, industrial, or household settingNitrofurantoin
go.drugbank.com/drugs/DB00698ApprovedInvestigationalVet approved[A179824] Nitrofurantoin is a second line treatment to [trimethoprim]/[sulfamethoxazole].[A179830] Nitrofurantoin was granted FDA approval on 6 February 1953.[L6895] … [A179824] This drug is more resistant to the development of bacterial resistance because it acts on many targets at once.
Categories: P-glycoprotein substrates, Heterocyclic Compounds, 1-RingSynonyms: N-(5-Nitrofurfurylidene)-1-aminohydantoin, 1-((5-nitro-2-furanyl)methylene)amino-2,4-imidazolidenedioneDacomitinib
go.drugbank.com/drugs/DB11963ApprovedInvestigational[L4810] Some evidence in the literature suggests the therapeutic potential of dacomitinib in the epithelial ovarian cancer model[A39624], although further investigations are needed. … Dacomitinib, designed as (2E)-N-16-4-(piperidin-1-yl) but-2-enamide, is an oral highly selective quinazalone part of the second-generation tyrosine kinase inhibitors which are characterized by the irreversible
Categories: Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic Index, P-glycoprotein substrates with a Narrow Therapeutic IndexEucalyptus oil
go.drugbank.com/drugs/DB11114ApprovedIt is shown to be effective in reducing pain, swelling, and inflammation via its modulatory effect on the immune response. … Eucalyptus oil is a distilled oil derived from the leaves of the tree Eucalyptus.
Mixtures: Cellzyme ON-TOX, Cellzyme ON-TOXSynonyms: Oil of eucalyptusPentose Phosphate Pathway
smpdb.ca/view/SMP0000031MetabolicThe pentose phosphate pathway—also referred to in the literature as the phosphogluconate pathway, the hexose monophosphate shunt, or the pentose phosphate shunt—is involved in the generation of NADPH as … The pentose phosphate pathway is also involved in the digestive process as the products of nucleic acid catabolism can be metabolized through the pathway (pentose sugars are usually yielded in the breakdown
Drugs: Adenosine phosphate · ATP · Magnesium cation · Iron · 5-O-phosphono-alpha-D-ribofuranosyl diphosphate · D-glyceraldehyde 3-phosphate +4 moreGlucose-6-phosphate Dehydrogenase Deficiency
smpdb.ca/view/SMP0125653DiseaseCarriers of the G6PDD allele may be partially protected against malaria, which explains the higher incidence of this genetic defect in people coming from countries that have or historically had malaria … About 400 million people (1 in 20) have G6PDD globally and it is particularly common in certain parts of Africa, Asia, the Mediterranean, and the Middle East.
Drugs: Adenosine phosphate · ATP · Magnesium cation · Iron · 5-O-phosphono-alpha-D-ribofuranosyl diphosphate · D-glyceraldehyde 3-phosphate +4 more