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Halofantrine
go.drugbank.com/drugs/DB01218ApprovedWithdrawnHalofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in th...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 SubstratesMethoxsalen
go.drugbank.com/drugs/DB00553ApprovedInvestigationalA naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA adducts in the presence of ultraviolet A irradiation.
Categories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 CYP2A6 InhibitorsHydroxyzine
go.drugbank.com/drugs/DB00557ApprovedInvestigationalHydroxyzine is a first-generation histamine H1-receptor antagonist of the dephenylmethane and piperazine classes that exhibits sedative, anxiolytic, and antiemetic properties. It was first developed in 1955, and has since remained a rela...
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesCephalexin
go.drugbank.com/drugs/DB00567ApprovedInvestigationalVet approvedCephalexin is the first of the first generation cephalosporins. This antibiotic contains a beta lactam and a dihydrothiazide. Cephalexin is used to treat a number of susceptible bacterial infections through inhibition of cell wall synthe...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesPropranolol
go.drugbank.com/drugs/DB00571ApprovedInvestigationalPropranolol is a racemic mixture of 2 enantiomers where the S(-)-enantiomer has approximately 100 times the binding affinity for beta adrenergic receptors. Propranolol is used to treat a number of conditions but most commonly is used for...
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesFenfluramine
go.drugbank.com/drugs/DB00574ApprovedIllicitInvestigationalWithdrawnDravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency an...
International brands: Ponderax PACategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesLisuride
go.drugbank.com/drugs/DB00589ApprovedAn ergot derivative that acts as an agonist at dopamine D2 receptors (dopamine agonists). It may also act as an antagonist at dopamine D1 receptors, and as an agonist at some serotonin receptors (serotonin agonists).
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesFluocinolone acetonide
go.drugbank.com/drugs/DB00591ApprovedInvestigationalVet approvedFluocinolone acetonide, with the formula 6-alpha, 9-alpha-difluoro-16-alpha, 17 alpha-acetonide, is a corticosteroid that presents a high lipophilicity. It has been used extensively in dermatological preparations and it has also been inv...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InducersThiopental
go.drugbank.com/drugs/DB00599ApprovedInvestigationalVet approvedWithdrawnA barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anesthesia of short duration. It is also used for hypnosis and for the control of convulsive states. It has been u...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InducersFluphenazine
go.drugbank.com/drugs/DB00623ApprovedA phenothiazine used in the treatment of psychoses. Its properties and uses are generally similar to those of chlorpromazine.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 CYP2D6 Inhibitors