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Serine/threonine-protein kinase DCLK1
go.drugbank.com/bio_entities/BE0009429TargetHumansProbable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system
Synonyms: Doublecortin-like and CAM kinase-like 1Serine/threonine-protein kinase DCLK3
go.drugbank.com/bio_entities/BE0009431TargetHumansSynonyms: Doublecortin-like and CAM kinase-like 3Omega-3-acid ethyl esters
go.drugbank.com/drugs/DB09539ApprovedInvestigationalOmega-3-acid ethyl esters are currently marketed in the US, EU, and many other regions under the brand name Lovaza[FDA Label][L5849]. … Omega-3-acid ethyl esters are prescription drugs that contain eicosapentaenoic acid-ethyl ester (EPA) and docosahexaenoic acid-ethyl ester (DHA) that are used in combination with changes in diet to lower
Categories: Diet, Food, and NutritionDNA damage-inducible transcript 4 protein
go.drugbank.com/bio_entities/BE0003445TargetHumansIts role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes (By similarity). … Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage.
Synonyms: Protein regulated in development and DNA damage response 1Caspase-4
go.drugbank.com/bio_entities/BE0009964TargetHumansCleavage of GSDMD is not strictly dependent on the consensus cleavage site but depends on an exosite interface on CASP4 that recognizes and binds the Gasdermin-D, C-terminal (GSDMD-CT) part (PubMed:32109412 … The non-canonical inflammasome is required for innate immunity to cytosolic, but not vacuolar, bacteria (By similarity).
Synonyms: ICE and Ced-3 homolog 2Hexachlorophene
go.drugbank.com/drugs/DB00756ApprovedWithdrawnIt is mainly used in soaps and creams and is an ingredient of various preparations used for skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p797) … A chlorinated bisphenol antiseptic with a bacteriostatic action against Gram-positive organisms, but much less effective against Gram-negative organisms.
Categories: Phenol and Derivatives, Antiseptics and DisinfectantsChlormadinone acetate
go.drugbank.com/drugs/DB15903ApprovedWithdrawnIn the US, chlormadinone acetate was formerly marketed as a component of the combination drug products Estalor-21 and C-Quens. … [L43942,L42975] Chlormadinone acetate continues to be used in other countries due to its high contraceptive efficacy and tolerability.[A254422,L33974]
Mixtures: BELARA film-coated tablet 0.03mg/2mgCategories: Hormones, Hormone Substitutes, and Hormone AntagonistsForeskin fibroblast (neonatal)
go.drugbank.com/drugs/DB10770ApprovedForeskin fibroblast-like stromal cells (FDSCs) are progenitors isolated from human tissue that can differentiate into various cell types [A32660]. … Dermagraft was introduced in the United Kingdom in October 1997, and several other European countries, as well as New Zealand and Australia.
Acid Cholesteryl Ester Hydrolase Deficiency, Wolman Type
go.drugbank.com/conditions/DBCOND0076044Drugs: Sebelipase alfaSynonyms: Deficiency of cholesterol esterase and triacylglycerol lipase